FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045381877> ?p ?o ?g. }

• W2045381877 endingPage "6393" @default.
• W2045381877 startingPage "6389" @default.
• W2045381877 abstract "Avian carcinoma virus MH2 contains two potential transforming genes, delta gag-mht and delta gag-myc. Thus, MH2 may be a model for two-gene carcinogenesis in which transformation depends on two synergistic genes. Most other directly oncogenic viruses contain single, autonomous transforming (onc) genes and are models for single-gene carcinogenesis. To determine which role each potential onc gene of MH2 plays in oncogenesis, we have prepared deletion and frameshift mutants of each of the two MH2 genes by in vitro mutagenesis of cloned proviral DNA and have tested transforming function and virus production in cultured primary quail cells. We have found that mht deletion mutants and wild-type virus transform primary cells and that myc deletion and frameshift mutants do not. The morphologies of cells transformed by the mht deletion mutants and by wild-type MH2 are similar yet vary considerably. Nevertheless, typical mutant transformed cells can often be distinguished from cells transformed by wild-type MH2. We conclude that the delta gag-myc gene transforms primary cells by itself, without the second potential onc gene. This myc-related gene is the smallest that has direct transforming function. delta gag-mht is without detectable transforming function but may affect transformation by delta gag-myc. Thus, MH2 behaves like a virus with a single onc gene, although it expresses two potential onc genes, and it appears not to be a model for two-gene carcinogenesis. Further work is necessary to determine whether the delta gag-mht gene possibly enhances oncogenic function of delta gag-myc or has independent oncogenic function in animals." @default.
• W2045381877 created "2016-06-24" @default.
• W2045381877 creator A5010111166 @default.
• W2045381877 creator A5045144563 @default.
• W2045381877 creator A5051537028 @default.
• W2045381877 creator A5077782098 @default.
• W2045381877 date "1985-10-01" @default.
• W2045381877 modified "2023-09-28" @default.
• W2045381877 title "Mutagenesis of avian carcinoma virus MH2: only one of two potential transforming genes (delta gag-myc) transforms fibroblasts." @default.
• W2045381877 cites W1511671200 @default.
• W2045381877 cites W1520054951 @default.
• W2045381877 cites W1790589966 @default.
• W2045381877 cites W1804431238 @default.
• W2045381877 cites W1889926369 @default.
• W2045381877 cites W1914348560 @default.
• W2045381877 cites W1964528687 @default.
• W2045381877 cites W1965086541 @default.
• W2045381877 cites W1965372133 @default.
• W2045381877 cites W1966412951 @default.
• W2045381877 cites W1974455897 @default.
• W2045381877 cites W1987600685 @default.
• W2045381877 cites W1996372785 @default.
• W2045381877 cites W1997316493 @default.
• W2045381877 cites W2000364619 @default.
• W2045381877 cites W2007456550 @default.
• W2045381877 cites W2007784773 @default.
• W2045381877 cites W2009838752 @default.
• W2045381877 cites W2022081023 @default.
• W2045381877 cites W2029532014 @default.
• W2045381877 cites W2039566585 @default.
• W2045381877 cites W2048125192 @default.
• W2045381877 cites W2052975271 @default.
• W2045381877 cites W2054398779 @default.
• W2045381877 cites W2055464167 @default.
• W2045381877 cites W2060354164 @default.
• W2045381877 cites W2068817943 @default.
• W2045381877 cites W2072580586 @default.
• W2045381877 cites W2077077811 @default.
• W2045381877 cites W2078667630 @default.
• W2045381877 cites W2081291936 @default.
• W2045381877 cites W2085093642 @default.
• W2045381877 cites W2094804194 @default.
• W2045381877 cites W2095081971 @default.
• W2045381877 cites W2095428305 @default.
• W2045381877 cites W2096510737 @default.
• W2045381877 cites W2128856125 @default.
• W2045381877 cites W2139103158 @default.
• W2045381877 cites W2160217059 @default.
• W2045381877 cites W2256930883 @default.
• W2045381877 cites W2273014572 @default.
• W2045381877 cites W54837359 @default.
• W2045381877 doi "https://doi.org/10.1073/pnas.82.19.6389" @default.
• W2045381877 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/390721" @default.
• W2045381877 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3876558" @default.
• W2045381877 hasPublicationYear "1985" @default.
• W2045381877 type Work @default.
• W2045381877 sameAs 2045381877 @default.
• W2045381877 citedByCount "28" @default.
• W2045381877 crossrefType "journal-article" @default.
• W2045381877 hasAuthorship W2045381877A5010111166 @default.
• W2045381877 hasAuthorship W2045381877A5045144563 @default.
• W2045381877 hasAuthorship W2045381877A5051537028 @default.
• W2045381877 hasAuthorship W2045381877A5077782098 @default.
• W2045381877 hasBestOaLocation W20453818771 @default.
• W2045381877 hasConcept C104317684 @default.
• W2045381877 hasConcept C143065580 @default.
• W2045381877 hasConcept C153911025 @default.
• W2045381877 hasConcept C16318435 @default.
• W2045381877 hasConcept C204241405 @default.
• W2045381877 hasConcept C2522874641 @default.
• W2045381877 hasConcept C29906990 @default.
• W2045381877 hasConcept C501734568 @default.
• W2045381877 hasConcept C54355233 @default.
• W2045381877 hasConcept C555283112 @default.
• W2045381877 hasConcept C86803240 @default.
• W2045381877 hasConceptScore W2045381877C104317684 @default.
• W2045381877 hasConceptScore W2045381877C143065580 @default.
• W2045381877 hasConceptScore W2045381877C153911025 @default.
• W2045381877 hasConceptScore W2045381877C16318435 @default.
• W2045381877 hasConceptScore W2045381877C204241405 @default.
• W2045381877 hasConceptScore W2045381877C2522874641 @default.
• W2045381877 hasConceptScore W2045381877C29906990 @default.
• W2045381877 hasConceptScore W2045381877C501734568 @default.
• W2045381877 hasConceptScore W2045381877C54355233 @default.
• W2045381877 hasConceptScore W2045381877C555283112 @default.
• W2045381877 hasConceptScore W2045381877C86803240 @default.
• W2045381877 hasIssue "19" @default.
• W2045381877 hasLocation W20453818771 @default.
• W2045381877 hasLocation W20453818772 @default.
• W2045381877 hasLocation W20453818773 @default.
• W2045381877 hasLocation W20453818774 @default.
• W2045381877 hasOpenAccess W2045381877 @default.
• W2045381877 hasPrimaryLocation W20453818771 @default.
• W2045381877 hasRelatedWork W188926022 @default.
• W2045381877 hasRelatedWork W1913380961 @default.
• W2045381877 hasRelatedWork W1994386041 @default.
• W2045381877 hasRelatedWork W2009647017 @default.
• W2045381877 hasRelatedWork W2012172239 @default.

• next