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• W2045383897 abstract "An experimental rat model for <i>Streptococcus pneumoniae</i> otitis media was used to investigate passive protection by anti-type 3 capsular antibodies and effects of immunization with pneumococcal surface protein A (PspA). Anti-type 3 antibodies instilled into the middle ear reduced purulent otitis media as compared to control animals (p = 0.015). Secondly, after immunization with PspA, the right middle ear was inoculated with <i>S. pneumoniae</i> type 6A in a dose calibrated to induce purulent otitis media. There was an anti-PspA antibody response in all rats immunized and a reduction in signs of purulent otitis media as compared to control animals (p = 0.026). Thus, purulent (acute) otitis media can be reduced by local application of antibodies in the middle ear and also by immunization with a non-type-specific pneumococcal protein, PspA." @default.
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• W2045383897 date "1999-01-01" @default.
• W2045383897 modified "2023-09-26" @default.
• W2045383897 title "Effects of Active Immunization with a Pneumococcal Surface Protein (PspA) and of Locally Applied Antibodies in Experimental Otitis media" @default.
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• W2045383897 doi "https://doi.org/10.1159/000027672" @default.
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