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• W2045385622 abstract "Summary Background : The role of gender in the progression of fibrosis in chronic hepatitis C is still under investigation. Aim : To investigate whether gender affects the progression of liver disease and/or hides other risk factors. Methods : A prospective series of 121 consecutive patients with chronic hepatitis C underwent liver biopsy. Grading and staging for chronic hepatitis were each evaluated according to Ishak's classification. Results : In univariate and multivariate analysis on the whole group of patients, male gender was not associated either with significant liver fibrosis (Ishak's score >2) or with cirrhosis (Ishak's score >4). On the contrary, in univariate analysis on patients aged ≤50 years, male gender was nearly significantly ( P = 0.06) predictive of liver fibrosis, whereas it was not in patients >50 years. Hepatic iron grading, along with age, was an independent factor associated with fibrosis. Moreover, the values of all the variables which describe iron status were significantly higher in males aged ≤50 years in comparison with females of the same age. Conclusions : In chronic hepatitis C, male gender may be predictive of liver fibrosis only in patients aged≤50 years. Among fibrogenetic factors hidden by gender, iron status could play a major role." @default.
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• W2045385622 date "2005-06-01" @default.
• W2045385622 modified "2023-10-16" @default.
• W2045385622 title "Gender and liver fibrosis in chronic hepatitis: the role of iron status" @default.
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• W2045385622 doi "https://doi.org/10.1111/j.1365-2036.2005.02517.x" @default.
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