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- W2045395557 abstract "In mice, thyroid feeding increases the response to intraperitoneally injected pentobarbital and thiopental, as demonstrated by increased mortality rates, prolonged sleep, and decreased activity. Pentobarbital is removed more slowly from the brain, liver, and plasma of thyroid-fed mice than from control mice. Thyroid-fed mice sleep longer from a given dose of pentobarbital. When they waken their tissue levels are the same as those found in control mice upon wakening. Thus, delayed drug removal (rather than heightened nervous system sensitivity) appears to explain increased barbiturate response in thyroid-fed mice. In mice propylthiouracil (PTU) feeding decreases the response (shorter sleep, less decrement of activity) to pentobarbital but not to thiopental. PTU feeding hastens the removal of pentobarbital from tissues. PTU-fed mice waken earlier than controls, at higher tissue levels. It is postulated that PTU induces increased activity of pentobarbital-destroying but not of thiopental-destroying enzymes. PTU may also have a direct action (decreased sensitivity to pentobarbital) on the nervous system. In rats thyroxin injection only slightly increases sleeping time and only slightly delays removal of pentobarbital from tissues after intravenous injection. Thyroidectomy grossly prolongs sleeping time and grossly delays removal of pentobarbital from tissues. Thus, in the rat, hyperthyroidism and hypothyroidism have similar qualitative effects on pentobarbital response. Thyroxin-injected, thyroidectomized, and control rats sleep for different periods of time after pentobarbital injection but waken at nearly identical tissue levels. Thyroid status appears to have no effect on the sensitivity of the nervous system of the rat to pentobarbital." @default.
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- W2045395557 title "The influence of thyroid status on the effects and metabolism of pentobarbital and thiopental" @default.
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- W2045395557 doi "https://doi.org/10.1016/0006-2952(66)90294-2" @default.
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