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- W2045397037 endingPage "272" @default.
- W2045397037 startingPage "259" @default.
- W2045397037 abstract "Ras superfamily small GTPases represent a wide and diverse class of intracellular signaling proteins that are highly conserved during evolution. These enzymes serve as key checkpoints in coupling antigen receptor, growth factor, cytokine and chemokine stimulation to cellular responses. Once activated, via their ability to regulate multiple downstream signaling pathways, small GTPases amplify and diversify signaling cascades which regulate cellular proliferation, survival, cytokine expression, trafficking and retention. Small GTPases, particularly members of the Ras, Rap, and Rho family, critically coordinate the function and interplay of immune and stromal cells during inflammatory respones, and increasing evidence indicates that alterations in small GTPase signaling contribute to the pathological behavior of these cell populations in human chronic inflammatory diseases such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Here, we review how Ras, Rap, and Rho family GTPases contribute to the biology of cell populations relevant to human chronic inflammatory disease, highlight recent advances in understanding how alterations in these pathways contribute to pathology in RA and SLE, and discuss new therapeutic strategies that may allow specific targeting of small GTPases in the clinic." @default.
- W2045397037 created "2016-06-24" @default.
- W2045397037 creator A5012564728 @default.
- W2045397037 creator A5074269237 @default.
- W2045397037 date "2012-09-07" @default.
- W2045397037 modified "2023-09-24" @default.
- W2045397037 title "Signal Transduction Pathways in Chronic Inflammatory Autoimmune Disease: Small GTPases" @default.
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