FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045400966> ?p ?o ?g. }

• W2045400966 endingPage "2072" @default.
• W2045400966 startingPage "2062" @default.
• W2045400966 abstract "Cell membranes and their lipids play critical roles in calcification. Specific membrane phospholipids promote the formation of calcium phosphate and become a part of the organic matrix of growing calcification. We propose that membrane lipids also promote the formation of calcium oxalate (CaOx) and calcium phosphate (CaP) containing kidney stones, and become a part of their stone matrix.Human urine, crystals of CaOx and CaP produced in the urine of healthy individuals, and urinary stones containing struvite, uric acid, CaOx and CaP crystals for the presence of membrane lipids were analyzed. Crystallization of CaOx monohydrate at Langmuir monolayers of dipalmitoylphosphatidylglycerol (DPPG), dipalmitoylphosphatidylcholine (DPPC), dipalmitoylphosphatidylserine (DPPS), dioleoylphosphatidylglycerol (DOPG), palmitoyloleoylphosphatidylglycerol (POPG) and dimyristoylphosphatidylglycerol (DMPG) was investigated to directly demonstrate that phospholipid assemblies can catalyze CaOx nucleation.Urine as well as CaOx and CaP crystals made in the urine and various types of urinary stones investigated contained some lipids. Urine of both CaOx and uric acid stone formers contained significantly more cholesterol, cholesterol ester and triglycerides than urine of healthy subjects. However, urine of CaOx stone formers contained more acidic phospholipids. The organic matrix of calcific stones contained significantly more acidic and complexed phospholipids than uric acid and struvite stones. For each Langmuir monolayer precipitation was heterogeneous and selective with respect to the orientation and morphology of the CaOx crystals. Crystals were predominantly monohydrate, and most often grew singly with the calcium rich (10-1) face toward the monolayer. The number of crystals/mm2 decreased in the order DPPG> DPPC and was inversely proportional to surface pressure and mean molecular area/molecule.Stone forming conditions in the kidneys greatly impact their epithelial cells producing significant differences in the urinary lipids between healthy and stone forming individuals. Altered membrane lipids promote face selective nucleation and retention of calcium oxalate crystals, and in the process become a part of the growing crystals and stones." @default.
• W2045400966 created "2016-06-24" @default.
• W2045400966 creator A5004010596 @default.
• W2045400966 creator A5015459244 @default.
• W2045400966 creator A5046366604 @default.
• W2045400966 creator A5076999762 @default.
• W2045400966 date "2002-12-01" @default.
• W2045400966 modified "2023-10-09" @default.
• W2045400966 title "Presence of lipids in urine, crystals and stones: Implications for the formation of kidney stones" @default.
• W2045400966 cites W1798204859 @default.
• W2045400966 cites W1966454020 @default.
• W2045400966 cites W1968837826 @default.
• W2045400966 cites W1969397542 @default.
• W2045400966 cites W1973281373 @default.
• W2045400966 cites W1976490615 @default.
• W2045400966 cites W1986024348 @default.
• W2045400966 cites W1994430162 @default.
• W2045400966 cites W1995253469 @default.
• W2045400966 cites W1995906052 @default.
• W2045400966 cites W1998061691 @default.
• W2045400966 cites W1999237623 @default.
• W2045400966 cites W1999605043 @default.
• W2045400966 cites W2010457940 @default.
• W2045400966 cites W2010738805 @default.
• W2045400966 cites W2019203744 @default.
• W2045400966 cites W2032515027 @default.
• W2045400966 cites W2043871861 @default.
• W2045400966 cites W2045566062 @default.
• W2045400966 cites W2045661887 @default.
• W2045400966 cites W2050250593 @default.
• W2045400966 cites W2051572288 @default.
• W2045400966 cites W2052024074 @default.
• W2045400966 cites W2053518235 @default.
• W2045400966 cites W2055398991 @default.
• W2045400966 cites W2062514829 @default.
• W2045400966 cites W2065114140 @default.
• W2045400966 cites W2073358942 @default.
• W2045400966 cites W2074240487 @default.
• W2045400966 cites W2084552518 @default.
• W2045400966 cites W2084938125 @default.
• W2045400966 cites W2139640966 @default.
• W2045400966 cites W2267309285 @default.
• W2045400966 cites W2323529181 @default.
• W2045400966 cites W2427356606 @default.
• W2045400966 cites W6323710 @default.
• W2045400966 doi "https://doi.org/10.1046/j.1523-1755.2002.00676.x" @default.
• W2045400966 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12427130" @default.
• W2045400966 hasPublicationYear "2002" @default.
• W2045400966 type Work @default.
• W2045400966 sameAs 2045400966 @default.
• W2045400966 citedByCount "111" @default.
• W2045400966 countsByYear W20454009662012 @default.
• W2045400966 countsByYear W20454009662013 @default.
• W2045400966 countsByYear W20454009662014 @default.
• W2045400966 countsByYear W20454009662015 @default.
• W2045400966 countsByYear W20454009662016 @default.
• W2045400966 countsByYear W20454009662017 @default.
• W2045400966 countsByYear W20454009662018 @default.
• W2045400966 countsByYear W20454009662020 @default.
• W2045400966 countsByYear W20454009662021 @default.
• W2045400966 countsByYear W20454009662022 @default.
• W2045400966 crossrefType "journal-article" @default.
• W2045400966 hasAuthorship W2045400966A5004010596 @default.
• W2045400966 hasAuthorship W2045400966A5015459244 @default.
• W2045400966 hasAuthorship W2045400966A5046366604 @default.
• W2045400966 hasAuthorship W2045400966A5076999762 @default.
• W2045400966 hasBestOaLocation W20454009661 @default.
• W2045400966 hasConcept C126322002 @default.
• W2045400966 hasConcept C178790620 @default.
• W2045400966 hasConcept C185592680 @default.
• W2045400966 hasConcept C2776179656 @default.
• W2045400966 hasConcept C2777132085 @default.
• W2045400966 hasConcept C2778918659 @default.
• W2045400966 hasConcept C2778999818 @default.
• W2045400966 hasConcept C2779403450 @default.
• W2045400966 hasConcept C2779881121 @default.
• W2045400966 hasConcept C2780026642 @default.
• W2045400966 hasConcept C41625074 @default.
• W2045400966 hasConcept C43617362 @default.
• W2045400966 hasConcept C519063684 @default.
• W2045400966 hasConcept C55493867 @default.
• W2045400966 hasConcept C71924100 @default.
• W2045400966 hasConceptScore W2045400966C126322002 @default.
• W2045400966 hasConceptScore W2045400966C178790620 @default.
• W2045400966 hasConceptScore W2045400966C185592680 @default.
• W2045400966 hasConceptScore W2045400966C2776179656 @default.
• W2045400966 hasConceptScore W2045400966C2777132085 @default.
• W2045400966 hasConceptScore W2045400966C2778918659 @default.
• W2045400966 hasConceptScore W2045400966C2778999818 @default.
• W2045400966 hasConceptScore W2045400966C2779403450 @default.
• W2045400966 hasConceptScore W2045400966C2779881121 @default.
• W2045400966 hasConceptScore W2045400966C2780026642 @default.
• W2045400966 hasConceptScore W2045400966C41625074 @default.
• W2045400966 hasConceptScore W2045400966C43617362 @default.
• W2045400966 hasConceptScore W2045400966C519063684 @default.
• W2045400966 hasConceptScore W2045400966C55493867 @default.
• W2045400966 hasConceptScore W2045400966C71924100 @default.
• W2045400966 hasIssue "6" @default.

• next