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- W2045401052 abstract "Abstract Aquaporins are a family of water channel proteins involved in water homeostasis in several tissues. Current knowledge of aquaporin expression in the nervous system is very limited. Therefore the first aim of this study was to assess, by immunohistochemistry and immunoblotting analysis, the presence and localization of aquaporin‐2 in the spinal cord and dorsal root ganglia of naïve adult rats. In addition, we evaluated aquaporin‐2 expression in response to chronic constriction injury of the sciatic nerve, a model of neuropathic pain. Our results showed that aquaporin‐2 expression was not detectable either in the spinal cord or the dorsal root ganglia of naïve rats. However, we showed for the first time an increase of aquaporin‐2 expression in response to chronic constriction injury treatment in small‐diameter dorsal root ganglia neurons but no expression in the lumbar spinal cord. These data support the hypothesis that aquaporin‐2 expression is involved in inflammatory neuropathic nerve injuries, although its precise role remains to be determined." @default.
- W2045401052 created "2016-06-24" @default.
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- W2045401052 date "2009-10-21" @default.
- W2045401052 modified "2023-10-16" @default.
- W2045401052 title "Chronic constriction injury induces aquaporin-2 expression in the dorsal root ganglia of rats" @default.
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- W2045401052 doi "https://doi.org/10.1111/j.1469-7580.2009.01143.x" @default.
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