FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045401188> ?p ?o ?g. }

• W2045401188 endingPage "1307" @default.
• W2045401188 startingPage "1297" @default.
• W2045401188 abstract "1. We examined the role of non-NMDA receptors in kainic acid (KA)-induced apoptosis in cultures of rat cerebellar granule cells (CGCs). KA (1 - 500 microM) induced cell death in a concentration-dependent manner, which was prevented by NBQX and GYKI 52466, non-NMDA receptor antagonists. Moreover, AMPA blocked KA-induced excitotoxicity, through desensitization of AMPA receptors. 2. Similarly, KA raised the intracellular calcium concentration of CGCs, which was inhibited by NBQX and GYKI 52466. Again, AMPA (100 microM) abolished the KA (100 microM)-induced increase in intracellular calcium concentration. 3. KA-induced cell death in CGCs had apoptotic features, which were determined morphologically, by DNA fragmentation, and by expression of the prostate apoptosis response-4 protein (Par-4). 5. KA (500 microM) slightly (18%) increased caspase-3 activity, which was strongly enhanced by colchicine (1 microM), an apoptotic stimulus. However, neither Z-VAD.fmk, a pan-caspase inhibitor, nor the more specific caspase-3 inhibitor, Ac-DEVD-CHO, prevented KA-induced cell death or apoptosis. In contrast, both drugs inhibited colchicine-induced apoptosis. 5. The calpain inhibitor ALLN had no effect on KA or colchicine-induced neurotoxicity. 6. Our findings indicate that colchicine-induced apoptosis in CGCs is mediated by caspase-3 activation, unlike KA-induced apoptosis." @default.
• W2045401188 created "2016-06-24" @default.
• W2045401188 creator A5009158490 @default.
• W2045401188 creator A5022621554 @default.
• W2045401188 creator A5023520893 @default.
• W2045401188 creator A5035256189 @default.
• W2045401188 creator A5042279812 @default.
• W2045401188 creator A5044204738 @default.
• W2045401188 creator A5062447911 @default.
• W2045401188 creator A5073770071 @default.
• W2045401188 creator A5074978554 @default.
• W2045401188 creator A5091575904 @default.
• W2045401188 date "2002-03-01" @default.
• W2045401188 modified "2023-10-18" @default.
• W2045401188 title "Kainic acid-induced neuronal cell death in cerebellar granule cells is not prevented by caspase inhibitors" @default.
• W2045401188 cites W126084106 @default.
• W2045401188 cites W1486649483 @default.
• W2045401188 cites W1522782595 @default.
• W2045401188 cites W1550601850 @default.
• W2045401188 cites W1622978237 @default.
• W2045401188 cites W1636078186 @default.
• W2045401188 cites W1899833653 @default.
• W2045401188 cites W1911014954 @default.
• W2045401188 cites W1965575645 @default.
• W2045401188 cites W1972733547 @default.
• W2045401188 cites W1975481676 @default.
• W2045401188 cites W1977632821 @default.
• W2045401188 cites W1979145429 @default.
• W2045401188 cites W1990192838 @default.
• W2045401188 cites W1990498941 @default.
• W2045401188 cites W1993280045 @default.
• W2045401188 cites W1996203960 @default.
• W2045401188 cites W1996568613 @default.
• W2045401188 cites W2003463004 @default.
• W2045401188 cites W2003574640 @default.
• W2045401188 cites W2008186920 @default.
• W2045401188 cites W2008254819 @default.
• W2045401188 cites W2008795665 @default.
• W2045401188 cites W2008964073 @default.
• W2045401188 cites W2009042957 @default.
• W2045401188 cites W2016332747 @default.
• W2045401188 cites W2017522921 @default.
• W2045401188 cites W2020580811 @default.
• W2045401188 cites W2029247738 @default.
• W2045401188 cites W2032844681 @default.
• W2045401188 cites W2034990409 @default.
• W2045401188 cites W2045281710 @default.
• W2045401188 cites W2047226001 @default.
• W2045401188 cites W2048952420 @default.
• W2045401188 cites W2051166364 @default.
• W2045401188 cites W2052129333 @default.
• W2045401188 cites W2054405716 @default.
• W2045401188 cites W2054526986 @default.
• W2045401188 cites W2057362398 @default.
• W2045401188 cites W2060865344 @default.
• W2045401188 cites W2062220574 @default.
• W2045401188 cites W2062798593 @default.
• W2045401188 cites W2067518219 @default.
• W2045401188 cites W2068848132 @default.
• W2045401188 cites W2072034156 @default.
• W2045401188 cites W2072821307 @default.
• W2045401188 cites W2074117052 @default.
• W2045401188 cites W2075078491 @default.
• W2045401188 cites W2082760399 @default.
• W2045401188 cites W2087860815 @default.
• W2045401188 cites W2088791795 @default.
• W2045401188 cites W2090815214 @default.
• W2045401188 cites W2095999492 @default.
• W2045401188 cites W2105517036 @default.
• W2045401188 cites W2107022871 @default.
• W2045401188 cites W2110211384 @default.
• W2045401188 cites W2120027781 @default.
• W2045401188 cites W2132273329 @default.
• W2045401188 cites W2139290875 @default.
• W2045401188 cites W2145408804 @default.
• W2045401188 cites W2168367599 @default.
• W2045401188 cites W2172126957 @default.
• W2045401188 cites W2273738402 @default.
• W2045401188 cites W2329132780 @default.
• W2045401188 cites W1758789593 @default.
• W2045401188 doi "https://doi.org/10.1038/sj.bjp.0704581" @default.
• W2045401188 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1573245" @default.
• W2045401188 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11877339" @default.
• W2045401188 hasPublicationYear "2002" @default.
• W2045401188 type Work @default.
• W2045401188 sameAs 2045401188 @default.
• W2045401188 citedByCount "42" @default.
• W2045401188 countsByYear W20454011882014 @default.
• W2045401188 countsByYear W20454011882016 @default.
• W2045401188 countsByYear W20454011882017 @default.
• W2045401188 countsByYear W20454011882018 @default.
• W2045401188 countsByYear W20454011882019 @default.
• W2045401188 countsByYear W20454011882020 @default.
• W2045401188 countsByYear W20454011882021 @default.
• W2045401188 countsByYear W20454011882022 @default.
• W2045401188 countsByYear W20454011882023 @default.
• W2045401188 crossrefType "journal-article" @default.
• W2045401188 hasAuthorship W2045401188A5009158490 @default.

• next