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- W2045402239 endingPage "150" @default.
- W2045402239 startingPage "140" @default.
- W2045402239 abstract "Access to novelty might provide an alternative learning history that competes with conditioned drug reward. We tested this suggestion in rats using a place conditioning procedure with cocaine and novelty. In Experiment 1, rats were conditioned with cocaine to prefer one side of an apparatus. In a subsequent phase, cocaine exposure continued; however, on the unpaired side, separate group of rats had access to novel objects, cocaine injections, or saline with no objects. Pairings with novel objects or cocaine shifted a preference away from the cocaine-paired environment during drug-free and drug-challenge tests. Experiment 2 tested novelty's impact when cocaine exposure was discontinued. The identical procedures were used except drug exposure ceased on the cocaine-paired side during the second phase. Both groups expressed a preference for the cocaine compartment. This preference was maintained for rats that did not have novel objects; however, rats that experienced novelty spent similar amounts of time in both compartments during both tests. Overall, the conditioned rewarding effects of novelty competed with those of cocaine as evidenced by a change in choice behaviors motivated by drug reward." @default.
- W2045402239 created "2016-06-24" @default.
- W2045402239 creator A5021211592 @default.
- W2045402239 creator A5035728419 @default.
- W2045402239 date "2008-01-01" @default.
- W2045402239 modified "2023-10-18" @default.
- W2045402239 title "Competition between the conditioned rewarding effects of cocaine and novelty." @default.
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- W2045402239 doi "https://doi.org/10.1037/0735-7044.122.1.140" @default.
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