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- W2045403944 abstract "A rapid method based on reversed-phase high-performance liquid chromatography is described for the separation and quantitation of azathioprine, 6-mercaptopurine and their potential contaminants and degradants present in dosage forms. Procedures based on simple dissolution or extraction in 0.02 M NaOH give quantitative precision of 1 % relative standard deviation at the macro-level and 2 % relative standard deviation for the micro-assay of analytes. The method is stability-indicating and has been used for preliminary studies of the degradation of azathiorine in 0.9 % sodium chloride injection, subjected to thermal or ultraviolet irradiation treatment. The content uniformity of dosage forms of azathioprine and 6-mercaptopurine has been measured Only azathioprine injection as the freeze-dried sodium salt ws found to contain detectable amounts of contaminants 6-mercaptopurine, 1-methyl-4-nitro-5-chloroimidazole and hypoxanthine." @default.
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- W2045403944 date "1979-12-01" @default.
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- W2045403944 title "Stability-indicating assay for azathioprine and 6-mercaptopurine by reversed-phase high-performance liquid chromatography" @default.
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- W2045403944 doi "https://doi.org/10.1016/s0021-9673(00)95289-0" @default.
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