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• W2045405791 endingPage "24" @default.
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• W2045405791 abstract "Time for primary review 23 days.Skeletal muscle, adipose tissue and liver are the quantitatively major targets for insulin action in vivo and regulation of critical steps in intermediary metabolism within these tissues account for many of the impacts of insulin on metabolic homeostasis. Many other tissues including the heart express insulin receptors and their functions may be importantly regulated by insulin. In this review we summarize the evidence that the heart is an important target of insulin action and that abrogation of these actions is important in disease states.Current understanding of the molecular basis of insulin actions on its target cells is drawn from a large literature emanating from studies of the major target tissues and also from a wide range of other cell types including studies of appropriately transfected and immortalized cell lines [1–4]. We introduce the basic concepts of the molecular basis of insulin actions, not to reiterate the extensive reviews recently published but rather to highlight aspects which are distinctive or which are poorly-defined in the heart. Our understanding of the biochemical mechanisms by which insulin exerts its effects in the heart are still substantially dependent upon extrapolation from studies of other cell types. It is important to recognize where such extrapolations may require qualification; we therefore focus particularly on the specific features of the myocardium which may lead to a distinct perspective of insulin action in this tissue.The actions of any individual external signal must be viewed in the context of a complex set of signals to which cells are exposed in vivo. Three issues are introduced (undoubtedly many more might deserve comment) to illustrate the importance of considering the basis against which we must attempt to judge the actions of insulin in the heart: (i) the constant pumping function of the … * Corresponding author. Tel.: +1 (604) 822-3810; Fax: +1 (604) 822-5227; e-mail: rogerb@unixg.ubc.ca" @default.
• W2045405791 created "2016-06-24" @default.
• W2045405791 creator A5031996352 @default.
• W2045405791 creator A5032964753 @default.
• W2045405791 creator A5076497150 @default.
• W2045405791 date "1997-04-01" @default.
• W2045405791 modified "2023-09-27" @default.
• W2045405791 title "Actions of insulin on the mammalian heart: metabolism, pathology and biochemical mechanisms" @default.
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