Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045406970> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2045406970 endingPage "211" @default.
- W2045406970 startingPage "205" @default.
- W2045406970 abstract "Human breast cancer cells selected for multidrug resistance frequently overexpress ligands and receptors in the epidermal growth factor (EGF) receptor family. To determine whether this overexpression contributes to the drug resistant phenotype, EGF receptor transfected ZR75B human breast cancer cells were examined. Two EGF receptor overexpressing clones were evaluated: clone 11 with >1 × 106 sites, and clone 13 with 310 000 receptor sites/cell. These were compared with clone 2-neo, which was transfected with the neomycin gene only and contained 43 000 receptor sites/cell. The EGF receptor overexpressing clones and the neo transfected control clone displayed comparable growth rates. Cytotoxicity analyses were performed with doxorubicin, vinblastine, cisplatin and 5-fluorouracil to determine the sensitivity of the clones to antineoplastic drugs. The EGF receptor overexpressing clones were found to be 1.5–5.6 times more resistant to the four drugs tested. This increase in the IC50 conferred a selective advantage when grown in the presence of 2, 3 and 6 ng/ml doxorubicin. Clone 13 cells overtook a mixed population which began with clone 2-neo comprising 95% of the cells. Clone 2-neo remained the dominant clone in the absence of drug. Finally, after long-term selection of the clones with 6 ng/ml doxorubicin, clone 2-neo became fourfold more resistant than the unselected clone 2-neo, a level which was comparable to that found in the EGF receptor overexpressing clones 11 and 13. No additional increase in resistance was observed for these clones, suggesting that clone 2-neo had developed additional resistance mechanisms. These results support the hypothesis that the EGF receptor pathway is able to confer a selective advantage to cells during drug exposure and potentially participates in the multidrug resistant phenotype." @default.
- W2045406970 created "2016-06-24" @default.
- W2045406970 creator A5013592290 @default.
- W2045406970 creator A5063492070 @default.
- W2045406970 creator A5066518495 @default.
- W2045406970 date "1995-04-01" @default.
- W2045406970 modified "2023-10-11" @default.
- W2045406970 title "Increased resistance to cytotoxic agents in ZR75B human breast cancer cells transfected with epidermal growth factor receptor" @default.
- W2045406970 cites W1598432003 @default.
- W2045406970 cites W1966801789 @default.
- W2045406970 cites W1974027176 @default.
- W2045406970 cites W1980518364 @default.
- W2045406970 cites W2001411958 @default.
- W2045406970 cites W2006102744 @default.
- W2045406970 cites W2014588425 @default.
- W2045406970 cites W2031933070 @default.
- W2045406970 cites W2036033314 @default.
- W2045406970 cites W2062713892 @default.
- W2045406970 cites W2076031566 @default.
- W2045406970 cites W2088658971 @default.
- W2045406970 cites W2109689528 @default.
- W2045406970 cites W2230845873 @default.
- W2045406970 cites W2315260956 @default.
- W2045406970 cites W2415460949 @default.
- W2045406970 cites W35929032 @default.
- W2045406970 cites W4237434210 @default.
- W2045406970 cites W4252105406 @default.
- W2045406970 cites W4362046093 @default.
- W2045406970 doi "https://doi.org/10.1016/0303-7207(95)03535-f" @default.
- W2045406970 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7672450" @default.
- W2045406970 hasPublicationYear "1995" @default.
- W2045406970 type Work @default.
- W2045406970 sameAs 2045406970 @default.
- W2045406970 citedByCount "59" @default.
- W2045406970 countsByYear W20454069702012 @default.
- W2045406970 countsByYear W20454069702013 @default.
- W2045406970 countsByYear W20454069702015 @default.
- W2045406970 countsByYear W20454069702019 @default.
- W2045406970 countsByYear W20454069702023 @default.
- W2045406970 crossrefType "journal-article" @default.
- W2045406970 hasAuthorship W2045406970A5013592290 @default.
- W2045406970 hasAuthorship W2045406970A5063492070 @default.
- W2045406970 hasAuthorship W2045406970A5066518495 @default.
- W2045406970 hasConcept C104317684 @default.
- W2045406970 hasConcept C153911025 @default.
- W2045406970 hasConcept C154317977 @default.
- W2045406970 hasConcept C170493617 @default.
- W2045406970 hasConcept C202751555 @default.
- W2045406970 hasConcept C2776362946 @default.
- W2045406970 hasConcept C502942594 @default.
- W2045406970 hasConcept C54009773 @default.
- W2045406970 hasConcept C54355233 @default.
- W2045406970 hasConcept C81089528 @default.
- W2045406970 hasConcept C81885089 @default.
- W2045406970 hasConcept C86803240 @default.
- W2045406970 hasConceptScore W2045406970C104317684 @default.
- W2045406970 hasConceptScore W2045406970C153911025 @default.
- W2045406970 hasConceptScore W2045406970C154317977 @default.
- W2045406970 hasConceptScore W2045406970C170493617 @default.
- W2045406970 hasConceptScore W2045406970C202751555 @default.
- W2045406970 hasConceptScore W2045406970C2776362946 @default.
- W2045406970 hasConceptScore W2045406970C502942594 @default.
- W2045406970 hasConceptScore W2045406970C54009773 @default.
- W2045406970 hasConceptScore W2045406970C54355233 @default.
- W2045406970 hasConceptScore W2045406970C81089528 @default.
- W2045406970 hasConceptScore W2045406970C81885089 @default.
- W2045406970 hasConceptScore W2045406970C86803240 @default.
- W2045406970 hasIssue "1-2" @default.
- W2045406970 hasLocation W20454069701 @default.
- W2045406970 hasLocation W20454069702 @default.
- W2045406970 hasOpenAccess W2045406970 @default.
- W2045406970 hasPrimaryLocation W20454069701 @default.
- W2045406970 hasRelatedWork W1524590520 @default.
- W2045406970 hasRelatedWork W2028084086 @default.
- W2045406970 hasRelatedWork W2034515275 @default.
- W2045406970 hasRelatedWork W2285828597 @default.
- W2045406970 hasRelatedWork W2372521113 @default.
- W2045406970 hasRelatedWork W2377327490 @default.
- W2045406970 hasRelatedWork W2385328945 @default.
- W2045406970 hasRelatedWork W2469005932 @default.
- W2045406970 hasRelatedWork W2481668549 @default.
- W2045406970 hasRelatedWork W2560253012 @default.
- W2045406970 hasVolume "110" @default.
- W2045406970 isParatext "false" @default.
- W2045406970 isRetracted "false" @default.
- W2045406970 magId "2045406970" @default.
- W2045406970 workType "article" @default.