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- W2045407557 abstract "• More than 60 zebrafish chemical screens have been reported since 2000. • We summarize the current practices in design of high-throughput zebrafish screens. • We summarize the types of phenotypic endpoints that have been used. • We describe the impact of zebrafish on chemical biology. • We highlight interesting examples of how mechanisms of action have been discovered. In 2000, the first chemical screen using living zebrafish in a multi-well plate was reported. Since then, more than 60 additional screens have been published describing whole-organism drug and pathway discovery projects in zebrafish. To investigate the scope of the work reported in the last 14 years and to identify trends in the field, we analyzed the discovery strategies of 64 primary research articles from the literature. We found that zebrafish screens have expanded beyond the use of developmental phenotypes to include behavioral, cardiac, metabolic, proliferative and regenerative endpoints. Additionally, many creative strategies have been used to uncover the mechanisms of action of new small molecules including chemical phenocopy, genetic phenocopy, mutant rescue, and spatial localization strategies." @default.
- W2045407557 created "2016-06-24" @default.
- W2045407557 creator A5048608610 @default.
- W2045407557 creator A5060379127 @default.
- W2045407557 date "2015-02-01" @default.
- W2045407557 modified "2023-10-12" @default.
- W2045407557 title "15 years of zebrafish chemical screening" @default.
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- W2045407557 doi "https://doi.org/10.1016/j.cbpa.2014.10.025" @default.
- W2045407557 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4339096" @default.
- W2045407557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25461724" @default.
- W2045407557 hasPublicationYear "2015" @default.
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