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- W2045409021 abstract "<h3>Objectives</h3> To identify the effect of direct renin inhibitor aliskiren on proliferation of vascular smooth muscle cells (VSMCs) induced by PDGF-BB, and study the mechanism of this effect. <h3>Methods</h3> The rats thoracic aorta smooth muscle cells (A10 cells) were used in the study, the effects of different concentrations of aliskiren and PDGF-BB as well as different stimulus durations of 10 μmol/L aliskiren and 20 ng/mL PDGF-BB stimulated on VSMCs proliferation was observed by [3H]-TdR; ERK, p-ERK and β-actin were assessed by immunoblotting. <h3>Results</h3> PDGF-BB could induce A10 cell proliferation, and the ratio of cell proliferation treated with 20 ng/mL PDGF-BB was (145.50 ± 10.51) % (P < 0.05) compared with the control group. Aliskiren could suppress PDGF-BB-induced proliferation of VSMCs, the ratio of cell proliferation treated with 20 ng/mL PDGF-BB plus 10 μmol/L aliskiren was (44.65 ± 24.42) % (P < 0.05) which is reduce compared with the cells treated with 20 ng/mL PDGF-BB alone. The effect of aliskiren ; immunoblotting showed that the effect of aliskiren on VSMC proliferation induced by PDGF-BB might be via ERK1/2 signal pathway. <h3>Conclusions</h3> Aliskiren suppressed PDGF-BB-induced proliferation of VSMCs, via ERK1/2 signal pathway." @default.
- W2045409021 created "2016-06-24" @default.
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- W2045409021 date "2013-08-01" @default.
- W2045409021 modified "2023-09-23" @default.
- W2045409021 title "GW24-e2369 Aliskiren inhibits proliferation of vascular smooth muscle cells induced by platelet-derived growth factor-BB via extracellular regulated protein kinases signal pathway" @default.
- W2045409021 doi "https://doi.org/10.1136/heartjnl-2013-304613.138" @default.
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