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- W2045412178 abstract "γδ T cells respond to stimulation via toll-like receptors (TLR). Bovine γδ T cells express TLR3 and TLR7, receptors that are key for the recognition of viruses such as bovine respiratory syncytial virus (BRSV); however, responses of γδ T cells to stimulation via these receptors, and their role during viral infections, remains unclear. Here, we demonstrate that neonatal bovine γδ T cells exhibit robust chemokine and cytokine production in response to the TLR3 agonist, Poly(I:C), and the TLR7 agonist, Imiquimod. Importantly, we observe a similar phenotype in γδ T-cell subsets purified from calves infected with BRSV. Bovine γδ T cells are divided into subsets based upon their expression of WC1, and the response to TLR stimulation and viral infection differs between these subsets, with WC1.1+ and WC1neg γδ T cells producing macrophage inflammatory protein-1α and granulocyte–macrophage colony-stimulating factor, and WC1.2+ γδ T cells preferentially producing the regulatory cytokines interleukin-10 and transforming growth factor-β. We further report that the active vitamin D metabolite 1,25-dihydroxyvitamin D3 does not alter γδ T-cell responses to TLR agonists or BRSV. To our knowledge, this is the first characterization of the γδ T-cell response during in vivo BRSV infection and the first suggestion that WC1.1+ and WC1neg γδ T cells contribute to the recruitment of inflammatory populations during viral infection. Based on our results, we propose that circulating γδ T cells are poised to rapidly respond to viral infection and suggest an important role for γδ T cells in the innate immune response of the bovine neonate." @default.
- W2045412178 created "2016-06-24" @default.
- W2045412178 creator A5023408977 @default.
- W2045412178 creator A5062843024 @default.
- W2045412178 creator A5074565889 @default.
- W2045412178 creator A5074870563 @default.
- W2045412178 creator A5080616173 @default.
- W2045412178 date "2013-04-23" @default.
- W2045412178 modified "2023-10-12" @default.
- W2045412178 title "Differential chemokine and cytokine production by neonatal bovine γδ T-cell subsets in response to viral toll-like receptor agonists and<i>in vivo</i>respiratory syncytial virus infection" @default.
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- W2045412178 doi "https://doi.org/10.1111/imm.12075" @default.
- W2045412178 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3647189" @default.
- W2045412178 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23368631" @default.
- W2045412178 hasPublicationYear "2013" @default.
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