Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045415841> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2045415841 abstract "Signaling events in eukaryotic cells are often guided by a scaffolding protein. Scaffold proteins assemble multiple proteins into a spatially localized signaling complex and exert numerous physical effects on signaling pathways. To study these effects, we consider a minimal, three-state kinetic model of scaffold-mediated kinase activation. We first introduce and apply a path summation technique to obtain approximate solutions to a single molecule master equation that governs protein kinase activation. We then consider exact numerical solutions. We comment on when this approximation is appropriate and then use this analysis to illustrate the competition of processes occurring at many time scales that are involved in signal transduction in the presence of a scaffold protein. We find that our minimal model captures how scaffold concentration can influence the times over which signaling is distributed in kinase cascades. For a range of scaffold concentrations, scaffolds allow for signaling to be distributed over multiple decades. The findings are consistent with recent experiments and simulation data. These results provide a framework and offer a mechanism for understanding how scaffold proteins can influence the shape of the waiting time distribution of kinase activation and effectively broaden the times over which protein kinases are activated in the course of cell signaling." @default.
- W2045415841 created "2016-06-24" @default.
- W2045415841 creator A5053106903 @default.
- W2045415841 date "2008-11-21" @default.
- W2045415841 modified "2023-10-05" @default.
- W2045415841 title "Three-state kinetic mechanism for scaffold-mediated signal transduction" @default.
- W2045415841 cites W1544401280 @default.
- W2045415841 cites W1973569897 @default.
- W2045415841 cites W1979218516 @default.
- W2045415841 cites W1980396134 @default.
- W2045415841 cites W1982644300 @default.
- W2045415841 cites W1982806451 @default.
- W2045415841 cites W2025381883 @default.
- W2045415841 cites W2034188706 @default.
- W2045415841 cites W2040391135 @default.
- W2045415841 cites W2043635727 @default.
- W2045415841 cites W2055519466 @default.
- W2045415841 cites W2067330392 @default.
- W2045415841 cites W2077507696 @default.
- W2045415841 cites W2086783008 @default.
- W2045415841 cites W2105191150 @default.
- W2045415841 cites W2107186290 @default.
- W2045415841 cites W2109261059 @default.
- W2045415841 cites W2112175922 @default.
- W2045415841 cites W2138391179 @default.
- W2045415841 cites W2139045279 @default.
- W2045415841 cites W2142337964 @default.
- W2045415841 cites W2156302599 @default.
- W2045415841 cites W2161313520 @default.
- W2045415841 cites W2163680039 @default.
- W2045415841 cites W2166364963 @default.
- W2045415841 cites W2167573033 @default.
- W2045415841 cites W2167960994 @default.
- W2045415841 doi "https://doi.org/10.1103/physreve.78.051921" @default.
- W2045415841 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2713820" @default.
- W2045415841 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19113169" @default.
- W2045415841 hasPublicationYear "2008" @default.
- W2045415841 type Work @default.
- W2045415841 sameAs 2045415841 @default.
- W2045415841 citedByCount "2" @default.
- W2045415841 crossrefType "journal-article" @default.
- W2045415841 hasAuthorship W2045415841A5053106903 @default.
- W2045415841 hasBestOaLocation W20454158412 @default.
- W2045415841 hasConcept C121332964 @default.
- W2045415841 hasConcept C12554922 @default.
- W2045415841 hasConcept C15152581 @default.
- W2045415841 hasConcept C184235292 @default.
- W2045415841 hasConcept C186060115 @default.
- W2045415841 hasConcept C41008148 @default.
- W2045415841 hasConcept C53645450 @default.
- W2045415841 hasConcept C62478195 @default.
- W2045415841 hasConcept C62520636 @default.
- W2045415841 hasConcept C70721500 @default.
- W2045415841 hasConcept C77088390 @default.
- W2045415841 hasConcept C86803240 @default.
- W2045415841 hasConcept C89429830 @default.
- W2045415841 hasConcept C89611455 @default.
- W2045415841 hasConcept C95444343 @default.
- W2045415841 hasConcept C97029542 @default.
- W2045415841 hasConceptScore W2045415841C121332964 @default.
- W2045415841 hasConceptScore W2045415841C12554922 @default.
- W2045415841 hasConceptScore W2045415841C15152581 @default.
- W2045415841 hasConceptScore W2045415841C184235292 @default.
- W2045415841 hasConceptScore W2045415841C186060115 @default.
- W2045415841 hasConceptScore W2045415841C41008148 @default.
- W2045415841 hasConceptScore W2045415841C53645450 @default.
- W2045415841 hasConceptScore W2045415841C62478195 @default.
- W2045415841 hasConceptScore W2045415841C62520636 @default.
- W2045415841 hasConceptScore W2045415841C70721500 @default.
- W2045415841 hasConceptScore W2045415841C77088390 @default.
- W2045415841 hasConceptScore W2045415841C86803240 @default.
- W2045415841 hasConceptScore W2045415841C89429830 @default.
- W2045415841 hasConceptScore W2045415841C89611455 @default.
- W2045415841 hasConceptScore W2045415841C95444343 @default.
- W2045415841 hasConceptScore W2045415841C97029542 @default.
- W2045415841 hasLocation W20454158411 @default.
- W2045415841 hasLocation W20454158412 @default.
- W2045415841 hasLocation W20454158413 @default.
- W2045415841 hasLocation W20454158414 @default.
- W2045415841 hasLocation W20454158415 @default.
- W2045415841 hasOpenAccess W2045415841 @default.
- W2045415841 hasPrimaryLocation W20454158411 @default.
- W2045415841 hasRelatedWork W1978760124 @default.
- W2045415841 hasRelatedWork W2004726042 @default.
- W2045415841 hasRelatedWork W2046865369 @default.
- W2045415841 hasRelatedWork W2096248361 @default.
- W2045415841 hasRelatedWork W2123013129 @default.
- W2045415841 hasRelatedWork W2146173859 @default.
- W2045415841 hasRelatedWork W2497751016 @default.
- W2045415841 hasRelatedWork W2595267503 @default.
- W2045415841 hasRelatedWork W2760868038 @default.
- W2045415841 hasRelatedWork W2907296586 @default.
- W2045415841 isParatext "false" @default.
- W2045415841 isRetracted "false" @default.
- W2045415841 magId "2045415841" @default.
- W2045415841 workType "article" @default.