FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045426250> ?p ?o ?g. }

• W2045426250 endingPage "533" @default.
• W2045426250 startingPage "527" @default.
• W2045426250 abstract "The effects of benzodiazepines on GABA(A) receptors are dependent largely on the particular α subunit isoform that is present in the receptor pentamer. The inclusion of either the α4 or α6 subunit is generally thought to render the receptor insensitive to classical benzodiazepines. We expressed the rat α4β3γ2L subtype in Xenopus oocytes and observed that both diazepam and flunitrazepam significantly potentiated GABA-gated currents. This potentiation occurred at nanomolar concentrations similar to those seen at the most abundant diazepam-sensitive receptor i.e., the α1β2γ2 subtype. In the α4β3γ2L receptor, the effects of diazepam and flunitrazepam were inhibited by nanomolar concentrations of the benzodiazepine site antagonists, Ro15-1788 and ZK93426. The presence of the β3 subunit appears to be important for this modulation since diazepam did not affect GABA responses mediated by recombinant α4β1γ2L or α4β2γ2L receptors. Interestingly, when the α4β3γ2L receptor was expressed in HEK293 cells, diazepam and flunitrazepam displaced the relatively non-selective benzodiazepine site ligand, [(3)H]Ro15-4513, only at high concentrations (>10 μM) demonstrating a lack of high affinity binding for these classical benzodiazepines. Functional studies of the cell-expressed receptors using whole cell recording techniques showed that neither diazepam nor flunitrazepam potentiated GABA-evoked currents although currents were enhanced by nanomolar concentrations of Ro15-4513. These results suggest that the observed benzodiazepine modulation of the α4β3γ2L subtype depends on the expression system used and may be specific for expression in Xenopus oocytes." @default.
• W2045426250 created "2016-06-24" @default.
• W2045426250 creator A5005516342 @default.
• W2045426250 creator A5013673965 @default.
• W2045426250 creator A5028401982 @default.
• W2045426250 creator A5045818246 @default.
• W2045426250 date "2010-11-01" @default.
• W2045426250 modified "2023-10-14" @default.
• W2045426250 title "Benzodiazepine modulation of the rat GABAA receptor α4β3γ2L subtype expressed in Xenopus oocytes" @default.
• W2045426250 cites W1482497049 @default.
• W2045426250 cites W1565551672 @default.
• W2045426250 cites W1710227085 @default.
• W2045426250 cites W1964287283 @default.
• W2045426250 cites W1972241193 @default.
• W2045426250 cites W1994831700 @default.
• W2045426250 cites W1999610563 @default.
• W2045426250 cites W2019043248 @default.
• W2045426250 cites W2048226090 @default.
• W2045426250 cites W2057046039 @default.
• W2045426250 cites W2061947653 @default.
• W2045426250 cites W2068375642 @default.
• W2045426250 cites W2071794798 @default.
• W2045426250 cites W2073538331 @default.
• W2045426250 cites W2074631079 @default.
• W2045426250 cites W2082678119 @default.
• W2045426250 cites W2086547360 @default.
• W2045426250 cites W2098762688 @default.
• W2045426250 cites W2105418849 @default.
• W2045426250 cites W2106001183 @default.
• W2045426250 cites W2123595571 @default.
• W2045426250 cites W2136657751 @default.
• W2045426250 cites W2165919627 @default.
• W2045426250 cites W2397339748 @default.
• W2045426250 cites W2409013290 @default.
• W2045426250 cites W3023841804 @default.
• W2045426250 cites W303540388 @default.
• W2045426250 doi "https://doi.org/10.1016/j.neuropharm.2010.07.011" @default.
• W2045426250 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20638393" @default.
• W2045426250 hasPublicationYear "2010" @default.
• W2045426250 type Work @default.
• W2045426250 sameAs 2045426250 @default.
• W2045426250 citedByCount "16" @default.
• W2045426250 countsByYear W20454262502012 @default.
• W2045426250 countsByYear W20454262502013 @default.
• W2045426250 countsByYear W20454262502015 @default.
• W2045426250 countsByYear W20454262502017 @default.
• W2045426250 countsByYear W20454262502018 @default.
• W2045426250 countsByYear W20454262502019 @default.
• W2045426250 countsByYear W20454262502021 @default.
• W2045426250 countsByYear W20454262502022 @default.
• W2045426250 crossrefType "journal-article" @default.
• W2045426250 hasAuthorship W2045426250A5005516342 @default.
• W2045426250 hasAuthorship W2045426250A5013673965 @default.
• W2045426250 hasAuthorship W2045426250A5028401982 @default.
• W2045426250 hasAuthorship W2045426250A5045818246 @default.
• W2045426250 hasConcept C104317684 @default.
• W2045426250 hasConcept C12554922 @default.
• W2045426250 hasConcept C126322002 @default.
• W2045426250 hasConcept C134018914 @default.
• W2045426250 hasConcept C168258287 @default.
• W2045426250 hasConcept C170493617 @default.
• W2045426250 hasConcept C185592680 @default.
• W2045426250 hasConcept C2776175493 @default.
• W2045426250 hasConcept C2778173252 @default.
• W2045426250 hasConcept C2779535977 @default.
• W2045426250 hasConcept C2781442855 @default.
• W2045426250 hasConcept C55493867 @default.
• W2045426250 hasConcept C71924100 @default.
• W2045426250 hasConcept C86803240 @default.
• W2045426250 hasConcept C98274493 @default.
• W2045426250 hasConceptScore W2045426250C104317684 @default.
• W2045426250 hasConceptScore W2045426250C12554922 @default.
• W2045426250 hasConceptScore W2045426250C126322002 @default.
• W2045426250 hasConceptScore W2045426250C134018914 @default.
• W2045426250 hasConceptScore W2045426250C168258287 @default.
• W2045426250 hasConceptScore W2045426250C170493617 @default.
• W2045426250 hasConceptScore W2045426250C185592680 @default.
• W2045426250 hasConceptScore W2045426250C2776175493 @default.
• W2045426250 hasConceptScore W2045426250C2778173252 @default.
• W2045426250 hasConceptScore W2045426250C2779535977 @default.
• W2045426250 hasConceptScore W2045426250C2781442855 @default.
• W2045426250 hasConceptScore W2045426250C55493867 @default.
• W2045426250 hasConceptScore W2045426250C71924100 @default.
• W2045426250 hasConceptScore W2045426250C86803240 @default.
• W2045426250 hasConceptScore W2045426250C98274493 @default.
• W2045426250 hasIssue "6" @default.
• W2045426250 hasLocation W20454262501 @default.
• W2045426250 hasLocation W20454262502 @default.
• W2045426250 hasOpenAccess W2045426250 @default.
• W2045426250 hasPrimaryLocation W20454262501 @default.
• W2045426250 hasRelatedWork W1987516826 @default.
• W2045426250 hasRelatedWork W1996020865 @default.
• W2045426250 hasRelatedWork W2003863749 @default.
• W2045426250 hasRelatedWork W2032566788 @default.
• W2045426250 hasRelatedWork W2035559758 @default.
• W2045426250 hasRelatedWork W2086746233 @default.
• W2045426250 hasRelatedWork W2142843765 @default.
• W2045426250 hasRelatedWork W2412572406 @default.

• next