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• W2045431763 abstract "Hypophosphatemia regularly occurs when high calorie-amino acid solutions devoid of phosphorus are administered intravenously. This hypophosphatemia is due to redistribution of phosphorus within the body, but the anatomical pattern of this redistribution has not been determined previously. Eleven male Sprague Dawley rats weighing approximately 200 g were starved for 4 days before being divided into two groups. Six rats were then fed a normal diet and the remaining five rats were hyperalimented intravenously with an amino acid/dextrose solution devoid of phosphorus. On the ninth day, when the hyperalimented rats were hypophosphatemic and hypophosphaturic, 0.2 ml of labeled plasma containing approximately 0.5 &i 32P was injected intravenously into each rat. One hour later the rats were exsanguinated under ether anesthesia, and the carcasses were dissected into organ compartments. Each organ was weighed, homogenized and digested, and aliquots were examined for radioactivity. The percentage recovery of injected anP was greater in the muscle mass of the phosphorus-free hyperalimented rats (24%) than in the control rats (15%), but was correspondingly less in the liver and gastrointestinal tract. Distribution of the labeled phosphorus to the other organs was similar in both groups. The results imply that hypophosphatemia during hyperalimentation is secondary to increased muscle anabolism. Since radiophosphorus is quickly incorporated into organic compounds within muscle, it is suggested that this increased turnover of phosphorus in muscle is associated with increased high energy phosphate metabolism. When amino acid/dextrose solutions which do not contain phosphorus are administered intravenously, hypophosphatemia often occurs within a few days [4, 91. Since the hypophosphatemia is accompanied by hypophosphaturia, it has been suggested that this rapid and profound hypophosphatemia is brought about by a massive compartmental shift of phosphorus from the extracellular fluid [12]. To date, the anatomic pattern of the distribution of body phosphorus during hyperalimentation hypophosphatemia has not been described. Hypophosphatemia can be associated with clinical symptoms [lo, 121, and detrimental changes in oxygen transport and leukocyte function have also been described [l, 8, 121. It is therefore of some importance that changes in phosphorus metabolism which occur during parenteral nutrition are well understood. Data are presented herein which describe the anatomical shifts of phosphorus which occur when an amino acid/dextrose nutrient solution devoid of phosphorus is administered intravenously." @default.
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• W2045431763 date "1976-06-01" @default.
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• W2045431763 title "Phosphorus distribution in hyperalimentation induced hypophosphatemia" @default.
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• W2045431763 doi "https://doi.org/10.1016/0022-4804(76)90086-x" @default.
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