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- W2045434536 abstract "Abstract An HPLC assay for the analysis of cisatracurium and its metabolites, laudanosine and the cis-monoquaternary alcohol (MQA), in human urine was developed. The assay involved solid-phase extraction followed by HPLC analysis on a strong cation exchange column with fluorescence detection. Linear regression was used to quantitate cisatracurium and its metabolites over the concentration ranges 10 to 2000 ng/mL for cisatracurium and 10 to 1000 ng/mL for the metabolites. The lower limit of quantitation for the assay was set at 10 ng/mL. The accuracy of the assay ranged from 6.6 to 17.0% for cisatracurium, -1.3 to 2.7% for laudanosine, and 0.2 to 3.4% for MQA. The precision of the assay ranged from 4.7 to 14.0% for cisatracurium, 4.6 to 7.7% for laudanosine, and 3.3 to 7.4% for MQA. The assay is specific for cisatracurium and its metabolites and no interfering endogenous peaks were observed in human urine. Cisatracurium, laudanosine and MQA were stable in acidified human urine (-20°C) for at least 9 months. Cisatracurium and its metabolites were also stable in acidified stock solutions and in urine after three freeze-thaw cycles. The mean recoveries for cisatracurium, laudanosine, MQA, and the internal standard from human urine were 104.4, 91.9, 91.9 and 93.4%, respectively." @default.
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- W2045434536 date "1997-07-01" @default.
- W2045434536 modified "2023-10-16" @default.
- W2045434536 title "High Performance Liquid Chromatographic Assay for Cisatracurium and Its Metabolites in Human Urine" @default.
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- W2045434536 doi "https://doi.org/10.1080/10826079708005563" @default.
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