FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045442575> ?p ?o ?g. }

• W2045442575 endingPage "85" @default.
• W2045442575 startingPage "82" @default.
• W2045442575 abstract "The P12A variant in the PPARG gene and the E23K polymorphism in KCNJ11 are both known to influence individual predisposition to type 2 diabetes. If the effect of these variants on insulin secretion and action were to extend to an influence on early growth (which is largely mediated by insulin), it would offer an explanation for observed associations between low birthweight and subsequent diabetes. Since previous studies of the effects of these variants on early growth have been limited and conflicting, we examined these associations in a large, well-characterised birth cohort.The P12A and E23K variants were genotyped in (respectively) 5,652 and 5,632 individuals from the Northern Finland Birth Cohort of 1966 and we sought associations with early growth phenotypes.Neither variant was associated with birthweight (P12A, p = 0.42; E23K, p = 0.44, additive models) or other measures of early growth. Although a previous report had suggested that the P12A effect on adult insulin sensitivity was restricted to small babies, we were unable to reproduce this finding (p = 0.40), nor did we confirm a previous report of an association with gestational age (p = 0.23).Despite a larger sample size than previous studies, we were unable to detect any effect of these variants on early growth. These findings do not support the notion that there are shared genetic determinants of low birthweight and adult diabetes." @default.
• W2045442575 created "2016-06-24" @default.
• W2045442575 creator A5007708528 @default.
• W2045442575 creator A5013273481 @default.
• W2045442575 creator A5014056725 @default.
• W2045442575 creator A5018096102 @default.
• W2045442575 creator A5034333560 @default.
• W2045442575 creator A5034710571 @default.
• W2045442575 creator A5049484171 @default.
• W2045442575 creator A5069340280 @default.
• W2045442575 creator A5089464396 @default.
• W2045442575 creator A5091356737 @default.
• W2045442575 date "2007-11-10" @default.
• W2045442575 modified "2023-10-10" @default.
• W2045442575 title "No evidence that established type 2 diabetes susceptibility variants in the PPARG and KCNJ11 genes have pleiotropic effects on early growth" @default.
• W2045442575 cites W2004956557 @default.
• W2045442575 cites W2006762991 @default.
• W2045442575 cites W2029485107 @default.
• W2045442575 cites W2044981852 @default.
• W2045442575 cites W2047173504 @default.
• W2045442575 cites W2083860117 @default.
• W2045442575 cites W2097660065 @default.
• W2045442575 cites W2122216533 @default.
• W2045442575 cites W2151172803 @default.
• W2045442575 cites W2170505333 @default.
• W2045442575 doi "https://doi.org/10.1007/s00125-007-0863-1" @default.
• W2045442575 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17994213" @default.
• W2045442575 hasPublicationYear "2007" @default.
• W2045442575 type Work @default.
• W2045442575 sameAs 2045442575 @default.
• W2045442575 citedByCount "14" @default.
• W2045442575 countsByYear W20454425752014 @default.
• W2045442575 countsByYear W20454425752015 @default.
• W2045442575 countsByYear W20454425752021 @default.
• W2045442575 countsByYear W20454425752023 @default.
• W2045442575 crossrefType "journal-article" @default.
• W2045442575 hasAuthorship W2045442575A5007708528 @default.
• W2045442575 hasAuthorship W2045442575A5013273481 @default.
• W2045442575 hasAuthorship W2045442575A5014056725 @default.
• W2045442575 hasAuthorship W2045442575A5018096102 @default.
• W2045442575 hasAuthorship W2045442575A5034333560 @default.
• W2045442575 hasAuthorship W2045442575A5034710571 @default.
• W2045442575 hasAuthorship W2045442575A5049484171 @default.
• W2045442575 hasAuthorship W2045442575A5069340280 @default.
• W2045442575 hasAuthorship W2045442575A5089464396 @default.
• W2045442575 hasAuthorship W2045442575A5091356737 @default.
• W2045442575 hasBestOaLocation W20454425751 @default.
• W2045442575 hasConcept C104317684 @default.
• W2045442575 hasConcept C126322002 @default.
• W2045442575 hasConcept C130241916 @default.
• W2045442575 hasConcept C134018914 @default.
• W2045442575 hasConcept C149737253 @default.
• W2045442575 hasConcept C180754005 @default.
• W2045442575 hasConcept C187345961 @default.
• W2045442575 hasConcept C2777180221 @default.
• W2045442575 hasConcept C2779234561 @default.
• W2045442575 hasConcept C2779306644 @default.
• W2045442575 hasConcept C2779434492 @default.
• W2045442575 hasConcept C46973012 @default.
• W2045442575 hasConcept C54355233 @default.
• W2045442575 hasConcept C555293320 @default.
• W2045442575 hasConcept C66322754 @default.
• W2045442575 hasConcept C71924100 @default.
• W2045442575 hasConcept C72563966 @default.
• W2045442575 hasConcept C86803240 @default.
• W2045442575 hasConceptScore W2045442575C104317684 @default.
• W2045442575 hasConceptScore W2045442575C126322002 @default.
• W2045442575 hasConceptScore W2045442575C130241916 @default.
• W2045442575 hasConceptScore W2045442575C134018914 @default.
• W2045442575 hasConceptScore W2045442575C149737253 @default.
• W2045442575 hasConceptScore W2045442575C180754005 @default.
• W2045442575 hasConceptScore W2045442575C187345961 @default.
• W2045442575 hasConceptScore W2045442575C2777180221 @default.
• W2045442575 hasConceptScore W2045442575C2779234561 @default.
• W2045442575 hasConceptScore W2045442575C2779306644 @default.
• W2045442575 hasConceptScore W2045442575C2779434492 @default.
• W2045442575 hasConceptScore W2045442575C46973012 @default.
• W2045442575 hasConceptScore W2045442575C54355233 @default.
• W2045442575 hasConceptScore W2045442575C555293320 @default.
• W2045442575 hasConceptScore W2045442575C66322754 @default.
• W2045442575 hasConceptScore W2045442575C71924100 @default.
• W2045442575 hasConceptScore W2045442575C72563966 @default.
• W2045442575 hasConceptScore W2045442575C86803240 @default.
• W2045442575 hasIssue "1" @default.
• W2045442575 hasLocation W20454425751 @default.
• W2045442575 hasLocation W20454425752 @default.
• W2045442575 hasOpenAccess W2045442575 @default.
• W2045442575 hasPrimaryLocation W20454425751 @default.
• W2045442575 hasRelatedWork W179030239 @default.
• W2045442575 hasRelatedWork W2121400944 @default.
• W2045442575 hasRelatedWork W2124791440 @default.
• W2045442575 hasRelatedWork W2170516263 @default.
• W2045442575 hasRelatedWork W2300880003 @default.
• W2045442575 hasRelatedWork W2619500281 @default.
• W2045442575 hasRelatedWork W3033817230 @default.
• W2045442575 hasRelatedWork W4285536231 @default.
• W2045442575 hasRelatedWork W4309375640 @default.
• W2045442575 hasRelatedWork W4311974439 @default.

• next