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- W2045444811 abstract "Two-photon-induced fluorescence spectrum and lifetime of Chlorin-e<sub>6</sub>-C<sub>15</sub> Monomethyl Ester in tetrahydrofura (THF) are experimentally examined with femtosecond laser pulses at 800 nm from a Ti:sapphire laser. The two-photon excited fluorescence spectra of the molecule are basically similar to those obtained by one-photon excitation. The lifetimes of two-photon and one-photon excitation fluorescence of this molecule in the solution are of the order of 5.2 ns and 4.8 ns respectively. Our experimental results indicate that the two-photon-induced photodynamic processes of Chlorin-e<sub>6</sub>-C<sub>15</sub> Monomethyl Ester are similar to one-photon-induced photodynamic processes. The two-photon absorption cross section of the molecule is measured at 800 nm as about σ<sub>2</sub><sup>'</sup> ≈ 29.1 x 10<sup>-50</sup> cm<sup>4</sup> • s/photon. As an example for two-photon photodynamic therapy, we also further examine the cell-damaging effects of the Ester. Our preliminary results of cell viability test indicate that Chlorin-e<sub>6</sub>-C<sub>15</sub> Monomethyl Ester can effectively damage the liver cancer cells BEL-7402 under two-photon irradiation. Our results suggest Chlorin-e<sub>6</sub>-C<sub>15</sub> Monomethyl Ester may become a potential two-photon phototherapeutic agent." @default.
- W2045444811 created "2016-06-24" @default.
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- W2045444811 date "2005-01-18" @default.
- W2045444811 modified "2023-09-26" @default.
- W2045444811 title "Two-photon excitation of chlorin-e 6 -C 15 monomethyl ester for photodynamic therapy" @default.
- W2045444811 doi "https://doi.org/10.1117/12.575941" @default.
- W2045444811 hasPublicationYear "2005" @default.
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