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- W2045446870 abstract "At present few vaccine candidates exists against potentially pandemic influenza virus infections. We provide compelling evidence that a targeted fusion protein based on the CTA1-DD adjuvant and containing tandem repeats of the matrix protein 2 (M2e) ectodomain epitope, CTA1-3M2e-DD, confers strong protective immunity against a potentially lethal challenge infection with influenza virus in mice. The formulation was highly effective for mucosal immunizations and promoted high M2e-specific serum IgG and mucosal IgA antibody titers and an hitherto unknown anti-M2e CD4 T cell immunity. This novel CTA1-3M2e-DD fusion protein combines adjuvant and a conserved influenza A antigen in a promising candidate for a universal anti-influenza vaccine." @default.
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- W2045446870 date "2008-02-01" @default.
- W2045446870 modified "2023-09-23" @default.
- W2045446870 title "CTA1-M2e-DD: A novel mucosal adjuvant targeted influenza vaccine" @default.
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- W2045446870 doi "https://doi.org/10.1016/j.vaccine.2007.12.027" @default.
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