FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045448966> ?p ?o ?g. }

• W2045448966 endingPage "170" @default.
• W2045448966 startingPage "164" @default.
• W2045448966 abstract "The Fanconi anemia pathway is involved in the repair of DNA interstrand cross-links, but it is also involved in regulation of translesion synthesis (TLS). The protein FAAP20 is now identified as a subunit of the Fanconi anemia core complex. FAAP20 interacts with TLS DNA polymerase Rev1, stabilizing Rev1's association with PCNA and promoting DNA damage bypass. The 15 known Fanconi anemia proteins cooperate in a pathway that regulates DNA interstrand cross-link repair. Recent studies indicate that the Fanconi anemia pathway also controls Rev1-mediated translesion DNA synthesis (TLS). We identified Fanconi anemia–associated protein (FAAP20), an integral subunit of the multisubunit Fanconi anemia core complex. FAAP20 binds to FANCA subunit and is required for stability of the complex and monoubiquitination of FANCD2. FAAP20 contains a ubiquitin-binding zinc finger 4 domain and binds to the monoubiquitinated form of Rev1. FAAP20 binding stabilizes Rev1 nuclear foci and promotes interaction of the Fanconi anemia core with PCNA–Rev1 DNA damage bypass complexes. FAAP20 therefore provides a critical link between the Fanconi anemia pathway and TLS polymerase activity. We propose that the Fanconi anemia core complex regulates cross-link repair by channeling lesions to damage bypass pathways and preventing large DNA insertions and deletions." @default.
• W2045448966 created "2016-06-24" @default.
• W2045448966 creator A5016155551 @default.
• W2045448966 creator A5041508602 @default.
• W2045448966 creator A5044648110 @default.
• W2045448966 creator A5046361319 @default.
• W2045448966 date "2012-01-22" @default.
• W2045448966 modified "2023-10-11" @default.
• W2045448966 title "Regulation of Rev1 by the Fanconi anemia core complex" @default.
• W2045448966 cites W1547492706 @default.
• W2045448966 cites W1840855988 @default.
• W2045448966 cites W1967186447 @default.
• W2045448966 cites W1971580036 @default.
• W2045448966 cites W1973266695 @default.
• W2045448966 cites W1985713945 @default.
• W2045448966 cites W1989643386 @default.
• W2045448966 cites W1992511544 @default.
• W2045448966 cites W1998604023 @default.
• W2045448966 cites W2004125597 @default.
• W2045448966 cites W2005711961 @default.
• W2045448966 cites W2008398476 @default.
• W2045448966 cites W2012485321 @default.
• W2045448966 cites W2018179063 @default.
• W2045448966 cites W2022787288 @default.
• W2045448966 cites W2034747770 @default.
• W2045448966 cites W2036826205 @default.
• W2045448966 cites W2040350157 @default.
• W2045448966 cites W2044292152 @default.
• W2045448966 cites W2048590349 @default.
• W2045448966 cites W2049748848 @default.
• W2045448966 cites W2056068841 @default.
• W2045448966 cites W2059731486 @default.
• W2045448966 cites W2064387695 @default.
• W2045448966 cites W2066720885 @default.
• W2045448966 cites W2068724764 @default.
• W2045448966 cites W2070879510 @default.
• W2045448966 cites W2072747624 @default.
• W2045448966 cites W2084316239 @default.
• W2045448966 cites W2092113847 @default.
• W2045448966 cites W2093588191 @default.
• W2045448966 cites W2094849013 @default.
• W2045448966 cites W2095687961 @default.
• W2045448966 cites W2099367992 @default.
• W2045448966 cites W2101185225 @default.
• W2045448966 cites W2101372024 @default.
• W2045448966 cites W2112158920 @default.
• W2045448966 cites W2114776482 @default.
• W2045448966 cites W2114907977 @default.
• W2045448966 cites W2115638352 @default.
• W2045448966 cites W2131510695 @default.
• W2045448966 cites W2135858046 @default.
• W2045448966 cites W2156435713 @default.
• W2045448966 cites W2167668429 @default.
• W2045448966 cites W2169950973 @default.
• W2045448966 doi "https://doi.org/10.1038/nsmb.2222" @default.
• W2045448966 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3280818" @default.
• W2045448966 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22266823" @default.
• W2045448966 hasPublicationYear "2012" @default.
• W2045448966 type Work @default.
• W2045448966 sameAs 2045448966 @default.
• W2045448966 citedByCount "125" @default.
• W2045448966 countsByYear W20454489662012 @default.
• W2045448966 countsByYear W20454489662013 @default.
• W2045448966 countsByYear W20454489662014 @default.
• W2045448966 countsByYear W20454489662015 @default.
• W2045448966 countsByYear W20454489662016 @default.
• W2045448966 countsByYear W20454489662017 @default.
• W2045448966 countsByYear W20454489662018 @default.
• W2045448966 countsByYear W20454489662019 @default.
• W2045448966 countsByYear W20454489662020 @default.
• W2045448966 countsByYear W20454489662021 @default.
• W2045448966 countsByYear W20454489662022 @default.
• W2045448966 countsByYear W20454489662023 @default.
• W2045448966 crossrefType "journal-article" @default.
• W2045448966 hasAuthorship W2045448966A5016155551 @default.
• W2045448966 hasAuthorship W2045448966A5041508602 @default.
• W2045448966 hasAuthorship W2045448966A5044648110 @default.
• W2045448966 hasAuthorship W2045448966A5046361319 @default.
• W2045448966 hasBestOaLocation W20454489662 @default.
• W2045448966 hasConcept C104292427 @default.
• W2045448966 hasConcept C104317684 @default.
• W2045448966 hasConcept C134935766 @default.
• W2045448966 hasConcept C143425029 @default.
• W2045448966 hasConcept C153911025 @default.
• W2045448966 hasConcept C2756471 @default.
• W2045448966 hasConcept C2776653068 @default.
• W2045448966 hasConcept C2778124228 @default.
• W2045448966 hasConcept C2778993383 @default.
• W2045448966 hasConcept C54355233 @default.
• W2045448966 hasConcept C552990157 @default.
• W2045448966 hasConcept C86803240 @default.
• W2045448966 hasConcept C95444343 @default.
• W2045448966 hasConceptScore W2045448966C104292427 @default.
• W2045448966 hasConceptScore W2045448966C104317684 @default.
• W2045448966 hasConceptScore W2045448966C134935766 @default.
• W2045448966 hasConceptScore W2045448966C143425029 @default.
• W2045448966 hasConceptScore W2045448966C153911025 @default.
• W2045448966 hasConceptScore W2045448966C2756471 @default.

• next