FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045457996> ?p ?o ?g. }

• W2045457996 endingPage "81" @default.
• W2045457996 startingPage "73" @default.
• W2045457996 abstract "Agonist binding to GABAB receptors modulates the activity of the guanine nucleotide binding proteins, Go and Gi. These G proteins are ADP-ribosylated by pertussis toxin and this prevents them from coupling to the GABAB receptor resulting in a reduction in high-affinity GABAB binding. GTP, which binds to a different site on the G protein α subunit, also reduces the affinity of the receptor for the G protein, and this can be used as a “marker” for G protein-GABAB receptor linkage. We have examined GABAB binding site distribution in rat brain after unilateral intrahippocampal pertussis toxin injection in vivo, and after incubating brain slices in pertussis toxin in vitro, using the technique of receptor autoradiography. The effect of pertussis toxin was compared with that of GTPγS on GABAB binding. Intrahippocampal pertussis toxin administration reduced GABAB but not GABAA receptor binding and the effects appeared to be limited by pertussis toxin diffusion. More widespread reductions in GABAB binding were seen after incubation of brain slices in vitro but the extent varied in different brain regions. No reduction was detected in the corpus striatum. GABAB binding was also reduced in membranes prepared from cerebral cortex, hippocampus and cerebellum but there was no sigificant reduction in the corpus striatum after pertussis toxin treatment. GTPγS reduced GABAB binding to a similar extent in all areas studied irrespective of their sensitivity to pertussis toxin suggesting that while GABAB binding sites are linked to G proteins throughout the rat brain, those in the corpus striatum may be predominantly pertussis toxin insensitive." @default.
• W2045457996 created "2016-06-24" @default.
• W2045457996 creator A5012345334 @default.
• W2045457996 creator A5057662991 @default.
• W2045457996 creator A5058691777 @default.
• W2045457996 creator A5081986132 @default.
• W2045457996 date "1993-01-01" @default.
• W2045457996 modified "2023-10-14" @default.
• W2045457996 title "Regional effects of pertussis toxin in vivo and in vitro on GABAB receptor binding in rat brain" @default.
• W2045457996 cites W1547271459 @default.
• W2045457996 cites W1971984887 @default.
• W2045457996 cites W1974447314 @default.
• W2045457996 cites W1987197175 @default.
• W2045457996 cites W1991491352 @default.
• W2045457996 cites W1993303708 @default.
• W2045457996 cites W1996940871 @default.
• W2045457996 cites W2000964053 @default.
• W2045457996 cites W2000972710 @default.
• W2045457996 cites W2000982143 @default.
• W2045457996 cites W2001201602 @default.
• W2045457996 cites W2005668919 @default.
• W2045457996 cites W2026496191 @default.
• W2045457996 cites W2036236793 @default.
• W2045457996 cites W2042645082 @default.
• W2045457996 cites W2048602049 @default.
• W2045457996 cites W2057232383 @default.
• W2045457996 cites W2057391839 @default.
• W2045457996 cites W2059864318 @default.
• W2045457996 cites W2060177975 @default.
• W2045457996 cites W2066991732 @default.
• W2045457996 cites W2071161962 @default.
• W2045457996 cites W2075534158 @default.
• W2045457996 cites W2089557582 @default.
• W2045457996 cites W2095858175 @default.
• W2045457996 cites W2132198678 @default.
• W2045457996 cites W2149372271 @default.
• W2045457996 cites W2553460829 @default.
• W2045457996 cites W4233987775 @default.
• W2045457996 cites W4236316486 @default.
• W2045457996 doi "https://doi.org/10.1016/0306-4522(93)90183-g" @default.
• W2045457996 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8381927" @default.
• W2045457996 hasPublicationYear "1993" @default.
• W2045457996 type Work @default.
• W2045457996 sameAs 2045457996 @default.
• W2045457996 citedByCount "27" @default.
• W2045457996 countsByYear W20454579962015 @default.
• W2045457996 countsByYear W20454579962016 @default.
• W2045457996 countsByYear W20454579962020 @default.
• W2045457996 countsByYear W20454579962022 @default.
• W2045457996 crossrefType "journal-article" @default.
• W2045457996 hasAuthorship W2045457996A5012345334 @default.
• W2045457996 hasAuthorship W2045457996A5057662991 @default.
• W2045457996 hasAuthorship W2045457996A5058691777 @default.
• W2045457996 hasAuthorship W2045457996A5081986132 @default.
• W2045457996 hasConcept C101027131 @default.
• W2045457996 hasConcept C134018914 @default.
• W2045457996 hasConcept C153911025 @default.
• W2045457996 hasConcept C170493617 @default.
• W2045457996 hasConcept C185592680 @default.
• W2045457996 hasConcept C2778938600 @default.
• W2045457996 hasConcept C2780062018 @default.
• W2045457996 hasConcept C49773422 @default.
• W2045457996 hasConcept C513476851 @default.
• W2045457996 hasConcept C55493867 @default.
• W2045457996 hasConcept C80631254 @default.
• W2045457996 hasConcept C86803240 @default.
• W2045457996 hasConcept C98274493 @default.
• W2045457996 hasConceptScore W2045457996C101027131 @default.
• W2045457996 hasConceptScore W2045457996C134018914 @default.
• W2045457996 hasConceptScore W2045457996C153911025 @default.
• W2045457996 hasConceptScore W2045457996C170493617 @default.
• W2045457996 hasConceptScore W2045457996C185592680 @default.
• W2045457996 hasConceptScore W2045457996C2778938600 @default.
• W2045457996 hasConceptScore W2045457996C2780062018 @default.
• W2045457996 hasConceptScore W2045457996C49773422 @default.
• W2045457996 hasConceptScore W2045457996C513476851 @default.
• W2045457996 hasConceptScore W2045457996C55493867 @default.
• W2045457996 hasConceptScore W2045457996C80631254 @default.
• W2045457996 hasConceptScore W2045457996C86803240 @default.
• W2045457996 hasConceptScore W2045457996C98274493 @default.
• W2045457996 hasIssue "1" @default.
• W2045457996 hasLocation W20454579961 @default.
• W2045457996 hasLocation W20454579962 @default.
• W2045457996 hasOpenAccess W2045457996 @default.
• W2045457996 hasPrimaryLocation W20454579961 @default.
• W2045457996 hasRelatedWork W1561695981 @default.
• W2045457996 hasRelatedWork W1969623589 @default.
• W2045457996 hasRelatedWork W1980514179 @default.
• W2045457996 hasRelatedWork W1982866831 @default.
• W2045457996 hasRelatedWork W1982981607 @default.
• W2045457996 hasRelatedWork W2022635754 @default.
• W2045457996 hasRelatedWork W2022841740 @default.
• W2045457996 hasRelatedWork W2028173765 @default.
• W2045457996 hasRelatedWork W2046271526 @default.
• W2045457996 hasRelatedWork W2078060199 @default.
• W2045457996 hasVolume "52" @default.
• W2045457996 isParatext "false" @default.
• W2045457996 isRetracted "false" @default.

• next