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• W2045459581 abstract "HIC1 (hypermethylated in cancer 1) is a tumor suppressor gene located on chromosome 17p13.3, a region frequently hypermethylated or deleted in human neoplasias. In mouse, Hic1 is essential for embryonic development and exerts an antitumor role in adult animals. Since Hic1-deficient mice die perinatally, we generated a conditional Hic1 null allele by flanking the Hic1-coding region by loxP sites. When crossed to animals expressing Cre recombinase in a cell-specific manner, the Hic1 conditional mice will provide new insights into the function of Hic1 in developing and mature tissues. Additionally, we used gene targeting to replace sequence-encoding amino acids 186–893 of Hic1 by citrine fluorescent protein cDNA. We demonstrate that the distribution of Hic1-citrine fusion polypeptide corresponds to the expression pattern of wild-type Hic1. Consequently, Hic1-citrine “reporter” mice can be used to monitor the activity of the Hic1 locus using citrine fluorescence. genesis 49:142-151, 2011. © 2011 Wiley-Liss, Inc." @default.
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• W2045459581 date "2011-03-01" @default.
• W2045459581 modified "2023-10-18" @default.
• W2045459581 title "Generation of two modified mouse alleles of the Hic1 tumor suppressor gene" @default.
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• W2045459581 doi "https://doi.org/10.1002/dvg.20719" @default.
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