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• W2045461108 startingPage "646" @default.
• W2045461108 abstract "The hypothesis that prior cannabis exposure increases the likelihood of becoming addicted to other drugs can be evaluated by giving rats a history of tetrahydrocannabinol (THC) exposure, then allowing them to self-administer other drugs. In Experiment 1, THC pre-exposure did not alter the acquisition of cocaine self-administration or the amount of cocaine taken under a fixed-ratio 1 (FR1) schedule, with one response required for each injection. Under a progressive-ratio schedule, with the response requirement increasing exponentially with each injection, cocaine-seeking was significantly reduced in THC-exposed rats, suggesting that the regimen of THC exposure used in the present study caused cocaine to be devalued as a reinforcer. In contrast, in an earlier study that used the same regimen, a history of THC exposure did not alter the value of heroin as a reinforcer under the progressive-ratio schedule, but it increased heroin self-administration under the FR1 schedule. Experiment 2 examined how this regimen of THC pre-exposure alters the locomotor effects of cocaine and heroin. THC pre-exposure produced cross-tolerance to the motor-depressant effects of heroin; this may explain the shortened post-injection pauses exhibited by THC-exposed rats under FR1 heroin self-administration. When given cocaine, THC-exposed rats exhibited normal increases in locomotion, but they avoided the center of the open field, suggesting that this THC pre-exposure regimen enhances the anxiogenic effects of cocaine. This enhanced anxiogenic effect—which was verified in Experiment 3 using another model of anxiety, the light–dark test—may explain the reduced reinforcing value of cocaine observed in THC-exposed rats in Experiment 1." @default.
• W2045461108 created "2016-06-24" @default.
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• W2045461108 date "2006-05-31" @default.
• W2045461108 modified "2023-09-30" @default.
• W2045461108 title "Previous Exposure to THC Alters the Reinforcing Efficacy and Anxiety-Related Effects of Cocaine in Rats" @default.
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• W2045461108 doi "https://doi.org/10.1038/sj.npp.1301109" @default.
• W2045461108 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16738542" @default.
• W2045461108 hasPublicationYear "2006" @default.
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