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- W2045461387 abstract "In this study, a novel hollow liposome modified with a rabies virus glycoprotein peptide (RVG-liposome) was designed and synthesized for siRNA delivery to the brain. The resultant RVG-liposome was about 91 nm in diameter with a regular globular shape and hollow structure. siRNA was successfully encapsulated into the hollow cores of the RVG-liposome, achieving ∼75% entrapment efficacy while maintaining the nanodimensions of the RVG-liposome. The siRNA-loaded RVG-liposome can be effectively internalized and subsequently releases siRNA in bone marrow macrophages. With siRNA loading, the RVG-liposome mediated effective siRNA delivery and resulted in high transfection efficiency in U87 cells. MTT assay demonstrated that neither the RVG-liposomes themselves nor siRNA-loaded RVG-liposome showed cytotoxicity, even at high concentrations. Moreover, in vivo live imaging and fresh frozen sections showed that the RVG-liposome has the ability to cross the blood–brain barrier (BBB) and was preferably accumulated in the brain. Such a hollow RVG-liposome holds great promise as a non-viral vector for efficient and brain-targeting gene delivery." @default.
- W2045461387 created "2016-06-24" @default.
- W2045461387 creator A5009645785 @default.
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- W2045461387 date "2012-01-01" @default.
- W2045461387 modified "2023-10-16" @default.
- W2045461387 title "Brain-targeting gene delivery using a rabies virus glycoprotein peptide modulated hollow liposome: bio-behavioral study" @default.
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- W2045461387 doi "https://doi.org/10.1039/c2jm31675g" @default.
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