FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045462473> ?p ?o ?g. }

• W2045462473 endingPage "5371" @default.
• W2045462473 startingPage "5364" @default.
• W2045462473 abstract "A number of condensed azines, mostly belonging to the families of indeno-fused pyridazines (1), pyrimidines (2, 3), and 1,2,4-triazines (4, 5), were synthesized and evaluated in vitro as monoamine oxidase (MAO) A and B inhibitors. Most of them showed higher inhibition potency toward MAO-B, the most effective one being 3-(3-nitrophenyl)-9H-indeno[1,2-e] [1,2,4]triazin-9-one (4c), which displayed an IC50 value of 80 nM and proved to be 10-fold more potent than its [2,1-e] fusion isomer 5. Replacing the 3-phenyl group of the known indeno[1,2-c]pyridazin-5-one MAO-B inhibitors with a flexible phenoxymethyl group enhanced the inhibitory potency. The inhibition data highlighted the importance of the aza-heterocyclic scaffold in affecting the MAO isoform selectivity. The 3-phenyl derivatives with type 1, 4, and 5 scaffolds were inhibitors of MAO-B with little or no MAO-A effect, whereas 2- or 3-phenyl derivatives of type 2 and 3 pyrimidine-containing fusion isomers inhibited both isoenzymes with a structure-dependent preference toward MAO-A." @default.
• W2045462473 created "2016-06-24" @default.
• W2045462473 creator A5002231513 @default.
• W2045462473 creator A5022770284 @default.
• W2045462473 creator A5048477086 @default.
• W2045462473 creator A5051548402 @default.
• W2045462473 creator A5064318879 @default.
• W2045462473 creator A5073418658 @default.
• W2045462473 creator A5080796605 @default.
• W2045462473 creator A5086336840 @default.
• W2045462473 creator A5087168657 @default.
• W2045462473 date "2007-10-02" @default.
• W2045462473 modified "2023-10-17" @default.
• W2045462473 title "Synthesis and Monoamine Oxidase Inhibitory Activity of New Pyridazine-, Pyrimidine- and 1,2,4-Triazine-Containing Tricyclic Derivatives" @default.
• W2045462473 cites W119179597 @default.
• W2045462473 cites W1496188536 @default.
• W2045462473 cites W1531401772 @default.
• W2045462473 cites W1969431518 @default.
• W2045462473 cites W1971019239 @default.
• W2045462473 cites W1973677234 @default.
• W2045462473 cites W1975058685 @default.
• W2045462473 cites W1990917194 @default.
• W2045462473 cites W2010561544 @default.
• W2045462473 cites W2012516949 @default.
• W2045462473 cites W2019972207 @default.
• W2045462473 cites W2021374461 @default.
• W2045462473 cites W2026125515 @default.
• W2045462473 cites W2027096890 @default.
• W2045462473 cites W2029767858 @default.
• W2045462473 cites W2033773654 @default.
• W2045462473 cites W2045144396 @default.
• W2045462473 cites W2046204255 @default.
• W2045462473 cites W2048892555 @default.
• W2045462473 cites W2050864578 @default.
• W2045462473 cites W2071978545 @default.
• W2045462473 cites W2079154850 @default.
• W2045462473 cites W2093153735 @default.
• W2045462473 cites W2093781635 @default.
• W2045462473 cites W2095451361 @default.
• W2045462473 cites W2108364115 @default.
• W2045462473 cites W2120586432 @default.
• W2045462473 cites W2131961995 @default.
• W2045462473 cites W2132474236 @default.
• W2045462473 cites W2140988381 @default.
• W2045462473 cites W2951679156 @default.
• W2045462473 cites W4230248338 @default.
• W2045462473 cites W45272086 @default.
• W2045462473 doi "https://doi.org/10.1021/jm070728r" @default.
• W2045462473 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17910428" @default.
• W2045462473 hasPublicationYear "2007" @default.
• W2045462473 type Work @default.
• W2045462473 sameAs 2045462473 @default.
• W2045462473 citedByCount "36" @default.
• W2045462473 countsByYear W20454624732013 @default.
• W2045462473 countsByYear W20454624732014 @default.
• W2045462473 countsByYear W20454624732015 @default.
• W2045462473 countsByYear W20454624732016 @default.
• W2045462473 countsByYear W20454624732018 @default.
• W2045462473 countsByYear W20454624732019 @default.
• W2045462473 countsByYear W20454624732020 @default.
• W2045462473 countsByYear W20454624732021 @default.
• W2045462473 countsByYear W20454624732022 @default.
• W2045462473 countsByYear W20454624732023 @default.
• W2045462473 crossrefType "journal-article" @default.
• W2045462473 hasAuthorship W2045462473A5002231513 @default.
• W2045462473 hasAuthorship W2045462473A5022770284 @default.
• W2045462473 hasAuthorship W2045462473A5048477086 @default.
• W2045462473 hasAuthorship W2045462473A5051548402 @default.
• W2045462473 hasAuthorship W2045462473A5064318879 @default.
• W2045462473 hasAuthorship W2045462473A5073418658 @default.
• W2045462473 hasAuthorship W2045462473A5080796605 @default.
• W2045462473 hasAuthorship W2045462473A5086336840 @default.
• W2045462473 hasAuthorship W2045462473A5087168657 @default.
• W2045462473 hasConcept C118792377 @default.
• W2045462473 hasConcept C161790260 @default.
• W2045462473 hasConcept C178790620 @default.
• W2045462473 hasConcept C181199279 @default.
• W2045462473 hasConcept C185592680 @default.
• W2045462473 hasConcept C193042331 @default.
• W2045462473 hasConcept C202751555 @default.
• W2045462473 hasConcept C2776024655 @default.
• W2045462473 hasConcept C2776303721 @default.
• W2045462473 hasConcept C2777355660 @default.
• W2045462473 hasConcept C2777752497 @default.
• W2045462473 hasConcept C2779321679 @default.
• W2045462473 hasConcept C2781081902 @default.
• W2045462473 hasConcept C55493867 @default.
• W2045462473 hasConcept C57992300 @default.
• W2045462473 hasConcept C71240020 @default.
• W2045462473 hasConceptScore W2045462473C118792377 @default.
• W2045462473 hasConceptScore W2045462473C161790260 @default.
• W2045462473 hasConceptScore W2045462473C178790620 @default.
• W2045462473 hasConceptScore W2045462473C181199279 @default.
• W2045462473 hasConceptScore W2045462473C185592680 @default.
• W2045462473 hasConceptScore W2045462473C193042331 @default.
• W2045462473 hasConceptScore W2045462473C202751555 @default.
• W2045462473 hasConceptScore W2045462473C2776024655 @default.
• W2045462473 hasConceptScore W2045462473C2776303721 @default.

• next