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- W2045463453 abstract "We considered the hypothesis that antioxidant supplementation that increases aortic antioxidant concentrations would reduce autoantibody titer to MDA-LDL, a measure that may indicate in vivo oxidation. We assessed autoantibody titer to MDA-LDL in rabbits before and after 5 months of treatment with a nutritionally adequate hypercholesterolemic diet alone (control) or supplemented with synthetic alpha-tocopherol or probucol. Aortic cholesterol and antioxidants were assessed at the end of treatment. alpha-Tocopherol supplementation increased the ratio of aortic alpha-tocopherol to cholesterol by 20-30-fold, while probucol supplementation increased the ratio of aortic probucol to cholesterol to 4-13 micromol/mol. Before treatment, MDA-LDL autoantibody titer averaged 5.09 +/- 0.24 with no difference among groups (p =.53 by ANOVA). However, after treatment, autoantibody titers differed among groups (p <.03 by ANOVA). Autoantibody titers were similar in rabbits supplemented with alpha-tocopherol and probucol (3.69 +/- 0.21 and 3.73 +/- 0.48, respectively, p = 0.81), and 26% (p <.009) lower in antioxidant supplemented rabbits than unsupplemented hypercholesterolemic rabbits (5.03 +/- 0.47). There was an inverse J relationship between autoantibody titer after treatment and aortic alpha-tocopherol/cholesterol and probucol/cholesterol, with minimum values for autoantibody titers above 8-10 micromol antioxidant/mmol cholesterol. The results of this study are consistent with inhibition of in vivo intra-aortic oxidation when aortic alpha-tocopherol or probucol exceed 8-10 micro;mol/mmol cholesterol." @default.
- W2045463453 created "2016-06-24" @default.
- W2045463453 creator A5003255105 @default.
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- W2045463453 date "2001-09-01" @default.
- W2045463453 modified "2023-09-27" @default.
- W2045463453 title "α-tocopherol and probucol reduce autoantibody titer to MDA-LDL in hypercholesterolemic rabbits" @default.
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- W2045463453 cites W1977778060 @default.
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- W2045463453 cites W1991573315 @default.
- W2045463453 cites W1991726504 @default.
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- W2045463453 cites W1993662108 @default.
- W2045463453 cites W1995288656 @default.
- W2045463453 cites W1996512988 @default.
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- W2045463453 cites W2029783166 @default.
- W2045463453 cites W2031051743 @default.
- W2045463453 cites W2031817893 @default.
- W2045463453 cites W2032566777 @default.
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- W2045463453 cites W2045096999 @default.
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- W2045463453 cites W2055111376 @default.
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- W2045463453 doi "https://doi.org/10.1016/s0891-5849(01)00645-1" @default.
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