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- W2045467386 abstract "To determine pulmonary deposition, translocation and clearance of inhaled talc, 10-wk-old hamsters received a single 2-hr nose-only exposure to neutron-activated talc. Over a period of 4 months, the hamsters were killed in groups of four. Lungs, liver, kidneys, ovaries, skinned carcass and 2-day and 4-day excreta were collected for γ-ray analysis. The isotope 60Co was used to calculate the quantity of talc in all samples; in addition, the isotope 46Sc was used in a number of samples to check the validity of 60Co as a tracer for talc. From 20 to 80 μg talc, an estimated 6–8% of the inhaled quantity, was deposited in the alveoli. The biological half-life of the talc deposited in the alveoli was 7–10 days. Alveolar clearance was essentially complete 4 months after exposure. No translocation of talc to liver, kidneys, ovaries or other parts of the body was found. Several hundred micrograms of talc were found in the faecal samples. Results of a leaching study to be described elsewhere suggest that the picogram quantities of 60Co found in the urine probably represented leached 60Co absorbed in the gastro-intestinal tract." @default.
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- W2045467386 date "1977-01-01" @default.
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- W2045467386 title "Pulmonary deposition, translocation and clearance of inhaled neutron-activated talc in hamsters" @default.
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- W2045467386 doi "https://doi.org/10.1016/s0015-6264(77)80392-1" @default.
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