FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045471478> ?p ?o ?g. }

• W2045471478 endingPage "722" @default.
• W2045471478 startingPage "712" @default.
• W2045471478 abstract "The magnetic resonance imaging (MRI) performance of two liposome formulations incorporating amphiphilic 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-like GdIII complexes has been investigated both in vitro and in vivo. The complexes differ in one donor group of the coordination cage (carboxylate versus carboxoamide), and in the length (C12 versus C18) and the point of attachment of the aliphatic chains to the chelators. The in vitro 1H relaxometric characterisation of the systems, performed with a newly developed relaxation model that takes into account the contributions of the GdIII chelates pointing in- and outwards of the liposome, indicates that their efficacy is optimal in the range 0.5–1.5 T. The tetracarboxylic C12-containing liposomes (LIPO-GdDOTA(GAC12)2; GA=glutaric acid) are four-fold more efficient than the monoamide C18-based analogue (LIPO-GdDOTAMA(C18)2). Such a difference is also found in vivo at 1 T in a melanoma tumour model on mice. A few hours after intravenous injection, the T1 contrast enhancement in the organs where the nanovesicles typically distribute (liver, spleen, kidneys and tumour) is much higher for LIPO-GdDOTA(GAC12)2. Interestingly, after about 7 h post-injection the contrast enhancement observed for the more efficient liposomes decreases rapidly and becomes lower than for LIPO-GdDOTAMA(C18)2. The relaxometric data and the quantification of the GdIII complexes in the organs, determined ex vivo by inductively coupled plasma mass spectrometry, indicate that: 1) the differences in the contrast enhancement can be attributed to the different rate of water exchange and rotational dynamics of the Gd complexes, and 2) the rapid contrast decrease is caused by a faster clearance of GdDOTA(GAC12)2 from the organs. This is also confirmed by using a newly synthesised amphiphilic cyanine-based fluorescent probe (Cy5-(C16)2). As one of the main limitations for the clinical translation of liposomes incorporating amphiphilic imaging agents is related to their very long persistence in the body, the results reported herein suggest that the clearance of the probes can be accelerated, without compromising their role, by a proper selection of the lipophilic portion of the incorporated compound as well as of the ligand site at which the aliphatic tails are linked. Then, GdDOTA(GAC12)2 complex may represent a good candidate for the development of improved MRI protocols based on paramagnetically labelled lipidic nanoparticles." @default.
• W2045471478 created "2016-06-24" @default.
• W2045471478 creator A5005452821 @default.
• W2045471478 creator A5006597366 @default.
• W2045471478 creator A5010109904 @default.
• W2045471478 creator A5026600177 @default.
• W2045471478 creator A5038724542 @default.
• W2045471478 creator A5075155207 @default.
• W2045471478 creator A5079933914 @default.
• W2045471478 creator A5090295380 @default.
• W2045471478 date "2013-06-03" @default.
• W2045471478 modified "2023-09-30" @default.
• W2045471478 title "In Vivo Magnetic Resonance Imaging Detection of Paramagnetic Liposomes Loaded with Amphiphilic Gadolinium(III) Complexes: Impact of Molecular Structure on Relaxivity and Excretion Efficiency" @default.
• W2045471478 cites W1577200064 @default.
• W2045471478 cites W1967453303 @default.
• W2045471478 cites W1975156383 @default.
• W2045471478 cites W1983143918 @default.
• W2045471478 cites W1995793167 @default.
• W2045471478 cites W1996234823 @default.
• W2045471478 cites W1997403945 @default.
• W2045471478 cites W2025717854 @default.
• W2045471478 cites W2029646788 @default.
• W2045471478 cites W2033503179 @default.
• W2045471478 cites W2035407013 @default.
• W2045471478 cites W2037048276 @default.
• W2045471478 cites W2043974985 @default.
• W2045471478 cites W2047112625 @default.
• W2045471478 cites W2050903854 @default.
• W2045471478 cites W2053590485 @default.
• W2045471478 cites W2065859376 @default.
• W2045471478 cites W2074532371 @default.
• W2045471478 cites W2084187009 @default.
• W2045471478 cites W2108615682 @default.
• W2045471478 cites W2118746879 @default.
• W2045471478 cites W2120646188 @default.
• W2045471478 cites W2124885334 @default.
• W2045471478 cites W2126346850 @default.
• W2045471478 cites W2142303435 @default.
• W2045471478 cites W2144611965 @default.
• W2045471478 cites W2158558808 @default.
• W2045471478 cites W2162171872 @default.
• W2045471478 cites W2166926604 @default.
• W2045471478 cites W2950428398 @default.
• W2045471478 cites W4232261023 @default.
• W2045471478 cites W47345933 @default.
• W2045471478 doi "https://doi.org/10.1002/cplu.201300096" @default.
• W2045471478 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31986622" @default.
• W2045471478 hasPublicationYear "2013" @default.
• W2045471478 type Work @default.
• W2045471478 sameAs 2045471478 @default.
• W2045471478 citedByCount "16" @default.
• W2045471478 countsByYear W20454714782014 @default.
• W2045471478 countsByYear W20454714782015 @default.
• W2045471478 countsByYear W20454714782016 @default.
• W2045471478 countsByYear W20454714782018 @default.
• W2045471478 countsByYear W20454714782019 @default.
• W2045471478 countsByYear W20454714782020 @default.
• W2045471478 countsByYear W20454714782021 @default.
• W2045471478 countsByYear W20454714782023 @default.
• W2045471478 crossrefType "journal-article" @default.
• W2045471478 hasAuthorship W2045471478A5005452821 @default.
• W2045471478 hasAuthorship W2045471478A5006597366 @default.
• W2045471478 hasAuthorship W2045471478A5010109904 @default.
• W2045471478 hasAuthorship W2045471478A5026600177 @default.
• W2045471478 hasAuthorship W2045471478A5038724542 @default.
• W2045471478 hasAuthorship W2045471478A5075155207 @default.
• W2045471478 hasAuthorship W2045471478A5079933914 @default.
• W2045471478 hasAuthorship W2045471478A5090295380 @default.
• W2045471478 hasConcept C121332964 @default.
• W2045471478 hasConcept C12554922 @default.
• W2045471478 hasConcept C126838900 @default.
• W2045471478 hasConcept C136339569 @default.
• W2045471478 hasConcept C143409427 @default.
• W2045471478 hasConcept C150903083 @default.
• W2045471478 hasConcept C15920480 @default.
• W2045471478 hasConcept C178790620 @default.
• W2045471478 hasConcept C185154212 @default.
• W2045471478 hasConcept C185592680 @default.
• W2045471478 hasConcept C197404232 @default.
• W2045471478 hasConcept C202751555 @default.
• W2045471478 hasConcept C207001950 @default.
• W2045471478 hasConcept C2778931785 @default.
• W2045471478 hasConcept C2778978742 @default.
• W2045471478 hasConcept C46141821 @default.
• W2045471478 hasConcept C521977710 @default.
• W2045471478 hasConcept C55493867 @default.
• W2045471478 hasConcept C557651011 @default.
• W2045471478 hasConcept C67407626 @default.
• W2045471478 hasConcept C71924100 @default.
• W2045471478 hasConcept C86803240 @default.
• W2045471478 hasConceptScore W2045471478C121332964 @default.
• W2045471478 hasConceptScore W2045471478C12554922 @default.
• W2045471478 hasConceptScore W2045471478C126838900 @default.
• W2045471478 hasConceptScore W2045471478C136339569 @default.
• W2045471478 hasConceptScore W2045471478C143409427 @default.
• W2045471478 hasConceptScore W2045471478C150903083 @default.
• W2045471478 hasConceptScore W2045471478C15920480 @default.
• W2045471478 hasConceptScore W2045471478C178790620 @default.

• next