FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045477037> ?p ?o ?g. }

• W2045477037 endingPage "46" @default.
• W2045477037 startingPage "35" @default.
• W2045477037 abstract "Congenital melanocytic nevi (CMNs) are melanocytic neoplasms that can transform into melanoma. However, this development is impeded in the majority of cases and mostly affects patients with large or giant CMNs.To elucidate mechanisms that keep CMNs from malignant transformation, CMN tissue biopsies were investigated for p-ERK and senescence markers by immunohistochemistry and for SOX10/CD271 (p75(NTR)) by immunofluorescence. CMN cells were cultivated, and MTT assays were performed for evaluating cell viability. Mutation status for NRAS and BRAF was performed by real-time PCR.13 CMNs (from patients aged 0.5-11.8 years, mean: 2.7) showed immunoreactivity for SOX10/CD271 (p75(NTR)) in 34.2%. p-ERK was immunoreactive in 80% (4/5); β-galactosidase was significantly stronger expressed in CMNs compared to melanocytic nevi of patients over 70 years (p = 0.0085). The 5 CMN cultures were immunoreactive for SOX10/CD271 (p75(NTR)) in 36.7%. By silencing SOX10 by siRNA in 2 CMN cell cultures, cell viability decreased significantly. NRAS(Q61K) mutation was found in 91.7% (11/12) and BRAF(V600E) in 6.3% of all analyzable CMNs (1/16).Oncogene-induced senescence might prevent malignant transformation through activation of the mitogen-activated protein kinase pathway. SOX10 is necessary for the viability of human CMN cell cultures and may be responsible for clinical changes during aging." @default.
• W2045477037 created "2016-06-24" @default.
• W2045477037 creator A5017247203 @default.
• W2045477037 creator A5021881332 @default.
• W2045477037 creator A5032415647 @default.
• W2045477037 creator A5045696330 @default.
• W2045477037 creator A5046436556 @default.
• W2045477037 creator A5048139572 @default.
• W2045477037 creator A5053106363 @default.
• W2045477037 creator A5058659054 @default.
• W2045477037 creator A5058953204 @default.
• W2045477037 creator A5064492239 @default.
• W2045477037 creator A5089297467 @default.
• W2045477037 date "2014-05-01" @default.
• W2045477037 modified "2023-10-17" @default.
• W2045477037 title "Coexpression of SOX10/CD271 (p75^NTR) and β-Galactosidase in Large to Giant Congenital Melanocytic Nevi of Pediatric Patients" @default.
• W2045477037 cites W1545583410 @default.
• W2045477037 cites W1958240725 @default.
• W2045477037 cites W1965736527 @default.
• W2045477037 cites W1967033366 @default.
• W2045477037 cites W1974481403 @default.
• W2045477037 cites W1974687777 @default.
• W2045477037 cites W1977874158 @default.
• W2045477037 cites W1984791357 @default.
• W2045477037 cites W1985577088 @default.
• W2045477037 cites W1996826567 @default.
• W2045477037 cites W1997094251 @default.
• W2045477037 cites W1998938134 @default.
• W2045477037 cites W2000981233 @default.
• W2045477037 cites W2003716893 @default.
• W2045477037 cites W2012318659 @default.
• W2045477037 cites W2015340967 @default.
• W2045477037 cites W2016260903 @default.
• W2045477037 cites W2020211855 @default.
• W2045477037 cites W2025005487 @default.
• W2045477037 cites W2026191833 @default.
• W2045477037 cites W2027098590 @default.
• W2045477037 cites W2045820236 @default.
• W2045477037 cites W2046137334 @default.
• W2045477037 cites W2048970845 @default.
• W2045477037 cites W2058000142 @default.
• W2045477037 cites W2060162388 @default.
• W2045477037 cites W2078008703 @default.
• W2045477037 cites W2078372576 @default.
• W2045477037 cites W2087343947 @default.
• W2045477037 cites W2093072027 @default.
• W2045477037 cites W2095112712 @default.
• W2045477037 cites W2097010979 @default.
• W2045477037 cites W2103489164 @default.
• W2045477037 cites W2107385057 @default.
• W2045477037 cites W2114918609 @default.
• W2045477037 cites W2129766846 @default.
• W2045477037 cites W2136474966 @default.
• W2045477037 cites W2138675861 @default.
• W2045477037 cites W2150740687 @default.
• W2045477037 cites W2161080185 @default.
• W2045477037 cites W2161554673 @default.
• W2045477037 cites W2162374867 @default.
• W2045477037 cites W2172202847 @default.
• W2045477037 doi "https://doi.org/10.1159/000362490" @default.
• W2045477037 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4772933" @default.
• W2045477037 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27047921" @default.
• W2045477037 hasPublicationYear "2014" @default.
• W2045477037 type Work @default.
• W2045477037 sameAs 2045477037 @default.
• W2045477037 citedByCount "1" @default.
• W2045477037 countsByYear W20454770372018 @default.
• W2045477037 crossrefType "journal-article" @default.
• W2045477037 hasAuthorship W2045477037A5017247203 @default.
• W2045477037 hasAuthorship W2045477037A5021881332 @default.
• W2045477037 hasAuthorship W2045477037A5032415647 @default.
• W2045477037 hasAuthorship W2045477037A5045696330 @default.
• W2045477037 hasAuthorship W2045477037A5046436556 @default.
• W2045477037 hasAuthorship W2045477037A5048139572 @default.
• W2045477037 hasAuthorship W2045477037A5053106363 @default.
• W2045477037 hasAuthorship W2045477037A5058659054 @default.
• W2045477037 hasAuthorship W2045477037A5058953204 @default.
• W2045477037 hasAuthorship W2045477037A5064492239 @default.
• W2045477037 hasAuthorship W2045477037A5089297467 @default.
• W2045477037 hasBestOaLocation W20454770371 @default.
• W2045477037 hasConcept C104317684 @default.
• W2045477037 hasConcept C126749454 @default.
• W2045477037 hasConcept C142724271 @default.
• W2045477037 hasConcept C184235292 @default.
• W2045477037 hasConcept C196843134 @default.
• W2045477037 hasConcept C21790070 @default.
• W2045477037 hasConcept C2777302934 @default.
• W2045477037 hasConcept C2781187634 @default.
• W2045477037 hasConcept C501734568 @default.
• W2045477037 hasConcept C502942594 @default.
• W2045477037 hasConcept C53227056 @default.
• W2045477037 hasConcept C54355233 @default.
• W2045477037 hasConcept C57074206 @default.
• W2045477037 hasConcept C71924100 @default.
• W2045477037 hasConcept C81885089 @default.
• W2045477037 hasConcept C86803240 @default.
• W2045477037 hasConcept C95444343 @default.
• W2045477037 hasConceptScore W2045477037C104317684 @default.

• next