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- W2045477870 abstract "The synthesis and photophysical studies of two cationic Tröger’s base (TB)-derived bis-naphthalimides 1 and 2 and the TB derivative 6, characterized by X-ray crystallography, are presented. The enantiomers of 1 and 2 are separated by cation-exchange chromatography on Sephadex C25 using sodium (−)-dibenzoyl-l-tartarate as the chiral mobile phase. The binding of enantiomers with salmon testes (st)-DNA and synthetic polynucleotides are studied by a variety of spectroscopic methods including UV/vis absorbance, circular dichroism, linear dichroism, and ethidium bromide displacement assays, which demonstrated binding of these compounds to the DNA grooves with very high affinity (K ∼ 106 M–1) and preferential binding of (−)-enantiomer. In all cases, binding to DNA resulted in a significant stabilization of the double-helical structure of DNA against thermal denaturation. Compound (±)-2 and its enantiomers possessed significantly higher binding affinity for double-stranded DNA compared to 1, possibly due to the presence of the methyl group, which allows favorable hydrophobic and van der Waals interactions with DNA. The TB derivatives exhibited marked preference for AT rich sequences, where the binding affinities follow the order (−)-enantiomer > (±) > (+)-enantiomer. The compounds exhibited significant photocleavage of plasmid DNA upon visible light irradiation and are rapidly internalized into malignant cell lines." @default.
- W2045477870 created "2016-06-24" @default.
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- W2045477870 date "2014-09-16" @default.
- W2045477870 modified "2023-10-14" @default.
- W2045477870 title "Supramolecular Approach to Enantioselective DNA Recognition Using Enantiomerically Resolved Cationic 4-Amino-1,8-naphthalimide-Based Tröger’s Bases" @default.
- W2045477870 cites W1497762792 @default.
- W2045477870 cites W1964440460 @default.
- W2045477870 cites W1964603841 @default.
- W2045477870 cites W1966497102 @default.
- W2045477870 cites W1972549231 @default.
- W2045477870 cites W1973605358 @default.
- W2045477870 cites W1974256758 @default.
- W2045477870 cites W1975637466 @default.
- W2045477870 cites W1975833163 @default.
- W2045477870 cites W1976182500 @default.
- W2045477870 cites W1976190619 @default.
- W2045477870 cites W1976337027 @default.
- W2045477870 cites W1979950718 @default.
- W2045477870 cites W1982631629 @default.
- W2045477870 cites W1983019869 @default.
- W2045477870 cites W1987200075 @default.
- W2045477870 cites W1987214053 @default.
- W2045477870 cites W1988675418 @default.
- W2045477870 cites W1989651677 @default.
- W2045477870 cites W1997031739 @default.
- W2045477870 cites W1997289646 @default.
- W2045477870 cites W1998700258 @default.
- W2045477870 cites W1999017743 @default.
- W2045477870 cites W1999696019 @default.
- W2045477870 cites W2001701387 @default.
- W2045477870 cites W2003582452 @default.
- W2045477870 cites W2011543269 @default.
- W2045477870 cites W2018466113 @default.
- W2045477870 cites W2018828292 @default.
- W2045477870 cites W2019276127 @default.
- W2045477870 cites W2019373389 @default.
- W2045477870 cites W2020586838 @default.
- W2045477870 cites W2023377960 @default.
- W2045477870 cites W2023435616 @default.
- W2045477870 cites W2028305226 @default.
- W2045477870 cites W2028669635 @default.
- W2045477870 cites W2028822407 @default.
- W2045477870 cites W2029763619 @default.
- W2045477870 cites W2029904731 @default.
- W2045477870 cites W2031086337 @default.
- W2045477870 cites W2035684460 @default.
- W2045477870 cites W2038856441 @default.
- W2045477870 cites W2038867138 @default.
- W2045477870 cites W2043757213 @default.
- W2045477870 cites W2048576571 @default.
- W2045477870 cites W2050608040 @default.
- W2045477870 cites W2052684317 @default.
- W2045477870 cites W2053142417 @default.
- W2045477870 cites W2057540703 @default.
- W2045477870 cites W2058598015 @default.
- W2045477870 cites W2060335449 @default.
- W2045477870 cites W2060992874 @default.
- W2045477870 cites W2061250423 @default.
- W2045477870 cites W2063243987 @default.
- W2045477870 cites W2064095363 @default.
- W2045477870 cites W2067059988 @default.
- W2045477870 cites W2068408092 @default.
- W2045477870 cites W2068810475 @default.
- W2045477870 cites W2069151183 @default.
- W2045477870 cites W2070232216 @default.
- W2045477870 cites W2077042698 @default.
- W2045477870 cites W2078819424 @default.
- W2045477870 cites W2079806181 @default.
- W2045477870 cites W2080948534 @default.
- W2045477870 cites W2084833940 @default.
- W2045477870 cites W2086415594 @default.
- W2045477870 cites W2087488740 @default.
- W2045477870 cites W2088189575 @default.
- W2045477870 cites W2088193828 @default.
- W2045477870 cites W2089592046 @default.
- W2045477870 cites W2098433031 @default.
- W2045477870 cites W2102766931 @default.
- W2045477870 cites W2111741521 @default.
- W2045477870 cites W2111757940 @default.
- W2045477870 cites W2123301821 @default.
- W2045477870 cites W2124116675 @default.
- W2045477870 cites W2127822578 @default.
- W2045477870 cites W2128294421 @default.
- W2045477870 cites W2131350133 @default.
- W2045477870 cites W2136189964 @default.
- W2045477870 cites W2142151252 @default.
- W2045477870 cites W2148745225 @default.
- W2045477870 cites W2152718279 @default.
- W2045477870 cites W2157048320 @default.
- W2045477870 cites W2159279834 @default.