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• W2045479541 startingPage "395" @default.
• W2045479541 abstract "Mouse skin melanocytes originate from the neural crest and subsequently invade the epidermis and migrate into the hair follicles (HF) where they proliferate and differentiate. Here we demonstrate a role for the chemokine SDF-1/CXCL12 and its receptor CXCR4 in regulating the migration and positioning of melanoblasts during HF formation and cycling. CXCR4 expression by melanoblasts was upregulated during the anagen phase of the HF cycle. CXCR4-expressing cells in the HF also expressed the stem cell markers nestin and LEX, the neural crest marker SOX10 and the cell proliferation marker PCNA. SDF-1 was widely expressed along the path taken by migrating CXCR4-expressing cells in the outer root sheath (ORS), suggesting that SDF-1-mediated signaling might be required for the migration of CXCR4 cells. Skin sections from CXCR4-deficient mice, and skin explants treated with the CXCR4 antagonist AMD3100, contained melanoblasts abnormally concentrated in the epidermis, consistent with a defect in their migration. SDF-1 acted as a chemoattractant for FACS-sorted cells isolated from the anagen skin of CXCR4-EGFP transgenic mice in vitro, and AMD3100 inhibited the SDF-1-induced migratory response. Together, these data demonstrate an important role for SDF-1/CXCR4 signaling in directing the migration and positioning of melanoblasts in the HF." @default.
• W2045479541 created "2016-06-24" @default.
• W2045479541 creator A5033597022 @default.
• W2045479541 creator A5061375376 @default.
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• W2045479541 creator A5081858203 @default.
• W2045479541 date "2009-04-01" @default.
• W2045479541 modified "2023-10-14" @default.
• W2045479541 title "The chemokine SDF-1/CXCL12 regulates the migration of melanocyte progenitors in mouse hair follicles" @default.
• W2045479541 cites W154745092 @default.
• W2045479541 cites W1857372604 @default.
• W2045479541 cites W1928152403 @default.
• W2045479541 cites W1973045008 @default.
• W2045479541 cites W1973877030 @default.
• W2045479541 cites W1974236886 @default.
• W2045479541 cites W1979670158 @default.
• W2045479541 cites W1980332250 @default.
• W2045479541 cites W1983724781 @default.
• W2045479541 cites W1985322254 @default.
• W2045479541 cites W1988672941 @default.
• W2045479541 cites W1991075591 @default.
• W2045479541 cites W1994254814 @default.
• W2045479541 cites W1996545028 @default.
• W2045479541 cites W2004426310 @default.
• W2045479541 cites W2004549688 @default.
• W2045479541 cites W2008205503 @default.
• W2045479541 cites W2010638326 @default.
• W2045479541 cites W2010703723 @default.
• W2045479541 cites W2017372544 @default.
• W2045479541 cites W2019204452 @default.
• W2045479541 cites W2019668010 @default.
• W2045479541 cites W2033119089 @default.
• W2045479541 cites W2035059684 @default.
• W2045479541 cites W2044560586 @default.
• W2045479541 cites W2044910712 @default.
• W2045479541 cites W2045278409 @default.
• W2045479541 cites W2045804249 @default.
• W2045479541 cites W2052623623 @default.
• W2045479541 cites W2059586395 @default.
• W2045479541 cites W2059979526 @default.
• W2045479541 cites W2061498997 @default.
• W2045479541 cites W2063568492 @default.
• W2045479541 cites W2067613633 @default.
• W2045479541 cites W2067760245 @default.
• W2045479541 cites W2073130433 @default.
• W2045479541 cites W2073337488 @default.
• W2045479541 cites W2076049418 @default.
• W2045479541 cites W2078145840 @default.
• W2045479541 cites W2079536616 @default.
• W2045479541 cites W2080360085 @default.
• W2045479541 cites W2081020835 @default.
• W2045479541 cites W2081853773 @default.
• W2045479541 cites W2083612980 @default.
• W2045479541 cites W2084881622 @default.
• W2045479541 cites W2087211932 @default.
• W2045479541 cites W2090985333 @default.
• W2045479541 cites W2092642979 @default.
• W2045479541 cites W2092930765 @default.
• W2045479541 cites W2094606090 @default.
• W2045479541 cites W2094725665 @default.
• W2045479541 cites W2098509726 @default.
• W2045479541 cites W2099410622 @default.
• W2045479541 cites W2104058491 @default.
• W2045479541 cites W2118903985 @default.
• W2045479541 cites W2119239047 @default.
• W2045479541 cites W2121876008 @default.
• W2045479541 cites W2122731703 @default.
• W2045479541 cites W2130987003 @default.
• W2045479541 cites W2135142758 @default.
• W2045479541 cites W2138143482 @default.
• W2045479541 cites W2138959209 @default.
• W2045479541 cites W2142792453 @default.
• W2045479541 cites W2145744287 @default.
• W2045479541 cites W2148463169 @default.
• W2045479541 cites W2151011478 @default.
• W2045479541 cites W2152112132 @default.
• W2045479541 cites W2156323704 @default.
• W2045479541 cites W2160776258 @default.
• W2045479541 cites W2161465706 @default.
• W2045479541 cites W2166663391 @default.
• W2045479541 cites W2170221117 @default.
• W2045479541 cites W2170833518 @default.
• W2045479541 cites W2172202847 @default.
• W2045479541 cites W2258885751 @default.
• W2045479541 cites W2444166999 @default.
• W2045479541 cites W4230752345 @default.
• W2045479541 cites W4255581519 @default.
• W2045479541 cites W99993573 @default.
• W2045479541 doi "https://doi.org/10.1016/j.diff.2008.10.015" @default.
• W2045479541 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4461245" @default.
• W2045479541 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19281787" @default.
• W2045479541 hasPublicationYear "2009" @default.
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