FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045479780> ?p ?o ?g. }

• W2045479780 endingPage "250" @default.
• W2045479780 startingPage "217" @default.
• W2045479780 abstract "Thyrotrophs, LH-and FSH-gonadotrophs have long been universally believed to be the three independent types of basophils responsible for production of corresponding hormones. In our preparations of normal rat pituitaries stained with aldehyde thionin-PAS-orange G, however, cell type distinction among these three kinds of basophils based on the staining property was found to be almost impossible, because of the intermediate forms frequently encountered, suggesting possible transformation of basophils among these types. The LH-gonadotroph may be, in our opinion, one of the intermediate forms between thyrotrophs and FSH-gonadotrophs. The same enlarged polygonal thyrotrophlike cell was studied by optical and electron microscopy on the adjacent two slices. Their intracellular thioniophilic site corresponds with accumulation of granules on the electron microscopic level. Electron density of these granules varied from low to high in each cell, sometimes giving the picture of haloed granules. Polygonal lean basophils with a row of granules with the diameter of 100-150mμ along the plasmamembrane were identified as the immature basophils, but not as the thyrotrophs. The same ovoid LH-gonadotrophlike cell was examined by optical and electron microscopy on the adjacent two slices. According to characteristics of their fine structure, they may be nothing but the young FSH-gonadotroph-like cells with scanty round vesicles and imperfect Golgi-ring. When chromophobes dissociated and collected with negligible contamination with granulated cells were cultured in the media added with a small amount of TRH or LH-RH, some of them were converted into FSH-gonadotroph-like cells. “Cell conversion” is thought to take place similarly from chromophobes to the terminal FSH-gonadotroph-like cells via either thyrotroph-like or LH-gonadotroph-like cells, regardless of the kind and dose of used RH. Based on these findings, the entire life stage of basophils originating from chromophobes was demonstrated in a system in vitro along with hormone bioassays of explants and media. Such “cell-metamorphosis” may follow the order of immature basophil (Type I) →thyrotroph-like cells (Type II) →LH-gonadotroph-like cells (Type III) →FSH-gonadotroph-like cells (TypeIV) →degenerating cells. The course of life stage of cultured chromophobes was as long as 30 or 50 days with the remarkable variation due to the dose of the added hormones. Continuous, stepwise intravenous injections of TRH for 7 hr occasionally gave rise to some castration-like effect on the basophils in rats. In systems not only in vitro but also in vivo, the life stage of the cells originating from chromophobes might progress chronically along the basophil-axis. When chromophobes in vivo transform into the thyrotroph-like cells, they could start to operate repeatedly their own short term secretory cycles. The fine structures of various types of basophils involved in a secretory cycle were demonstrated in the normal rats and those injected with TRH and LH-RH. FSH-gonadotroph-like cells filled with the expanded round vesicles tend to rapidly multiply within 5min after an injection of TRH or LH-RH; LH-gonadotrophlike and thyrotroph-like cells, containing the numerous granules associated with haloed granules and closed ER, become the predominant component of basophils of the glands within 10 (TRH) or 30min (LH-RH); optical and electron microscopic changes of three kinds of basophils return to the prestimulated status within 60 (TRH) and 180min (LH-RH). Two possibilities are discussed concerning the secretory cycle: One deals with only one secretory cycle common to the all types of basophils, and the other with three separated secretory cycles with regard to the thyrotroph, LH-and FSH-gonadotroph respectively." @default.
• W2045479780 created "2016-06-24" @default.
• W2045479780 creator A5002882010 @default.
• W2045479780 creator A5006267470 @default.
• W2045479780 creator A5029754272 @default.
• W2045479780 creator A5049987550 @default.
• W2045479780 date "1974-01-01" @default.
• W2045479780 modified "2023-10-15" @default.
• W2045479780 title "Life Stage and Secretory Cycle of Anterior Pituitary Basophils" @default.
• W2045479780 doi "https://doi.org/10.1507/endocrj1954.21.217" @default.
• W2045479780 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4139013" @default.
• W2045479780 hasPublicationYear "1974" @default.
• W2045479780 type Work @default.
• W2045479780 sameAs 2045479780 @default.
• W2045479780 citedByCount "7" @default.
• W2045479780 crossrefType "journal-article" @default.
• W2045479780 hasAuthorship W2045479780A5002882010 @default.
• W2045479780 hasAuthorship W2045479780A5006267470 @default.
• W2045479780 hasAuthorship W2045479780A5029754272 @default.
• W2045479780 hasAuthorship W2045479780A5049987550 @default.
• W2045479780 hasBestOaLocation W20454797801 @default.
• W2045479780 hasConcept C119062480 @default.
• W2045479780 hasConcept C120665830 @default.
• W2045479780 hasConcept C121332964 @default.
• W2045479780 hasConcept C126322002 @default.
• W2045479780 hasConcept C134018914 @default.
• W2045479780 hasConcept C141105273 @default.
• W2045479780 hasConcept C1491633281 @default.
• W2045479780 hasConcept C159654299 @default.
• W2045479780 hasConcept C184760221 @default.
• W2045479780 hasConcept C185592680 @default.
• W2045479780 hasConcept C197012351 @default.
• W2045479780 hasConcept C203014093 @default.
• W2045479780 hasConcept C2777456892 @default.
• W2045479780 hasConcept C2777658017 @default.
• W2045479780 hasConcept C54355233 @default.
• W2045479780 hasConcept C55493867 @default.
• W2045479780 hasConcept C71315377 @default.
• W2045479780 hasConcept C71924100 @default.
• W2045479780 hasConcept C74864618 @default.
• W2045479780 hasConcept C79879829 @default.
• W2045479780 hasConcept C86803240 @default.
• W2045479780 hasConcept C93877712 @default.
• W2045479780 hasConcept C95444343 @default.
• W2045479780 hasConceptScore W2045479780C119062480 @default.
• W2045479780 hasConceptScore W2045479780C120665830 @default.
• W2045479780 hasConceptScore W2045479780C121332964 @default.
• W2045479780 hasConceptScore W2045479780C126322002 @default.
• W2045479780 hasConceptScore W2045479780C134018914 @default.
• W2045479780 hasConceptScore W2045479780C141105273 @default.
• W2045479780 hasConceptScore W2045479780C1491633281 @default.
• W2045479780 hasConceptScore W2045479780C159654299 @default.
• W2045479780 hasConceptScore W2045479780C184760221 @default.
• W2045479780 hasConceptScore W2045479780C185592680 @default.
• W2045479780 hasConceptScore W2045479780C197012351 @default.
• W2045479780 hasConceptScore W2045479780C203014093 @default.
• W2045479780 hasConceptScore W2045479780C2777456892 @default.
• W2045479780 hasConceptScore W2045479780C2777658017 @default.
• W2045479780 hasConceptScore W2045479780C54355233 @default.
• W2045479780 hasConceptScore W2045479780C55493867 @default.
• W2045479780 hasConceptScore W2045479780C71315377 @default.
• W2045479780 hasConceptScore W2045479780C71924100 @default.
• W2045479780 hasConceptScore W2045479780C74864618 @default.
• W2045479780 hasConceptScore W2045479780C79879829 @default.
• W2045479780 hasConceptScore W2045479780C86803240 @default.
• W2045479780 hasConceptScore W2045479780C93877712 @default.
• W2045479780 hasConceptScore W2045479780C95444343 @default.
• W2045479780 hasIssue "3" @default.
• W2045479780 hasLocation W20454797801 @default.
• W2045479780 hasLocation W20454797802 @default.
• W2045479780 hasOpenAccess W2045479780 @default.
• W2045479780 hasPrimaryLocation W20454797801 @default.
• W2045479780 hasRelatedWork W1979895538 @default.
• W2045479780 hasRelatedWork W1981121424 @default.
• W2045479780 hasRelatedWork W1988347639 @default.
• W2045479780 hasRelatedWork W2018911409 @default.
• W2045479780 hasRelatedWork W2020033147 @default.
• W2045479780 hasRelatedWork W2046074461 @default.
• W2045479780 hasRelatedWork W2088879451 @default.
• W2045479780 hasRelatedWork W2161982920 @default.
• W2045479780 hasRelatedWork W2170681503 @default.
• W2045479780 hasRelatedWork W4571987 @default.
• W2045479780 hasVolume "21" @default.
• W2045479780 isParatext "false" @default.
• W2045479780 isRetracted "false" @default.
• W2045479780 magId "2045479780" @default.
• W2045479780 workType "article" @default.