Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045484927> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2045484927 abstract "1. The effects of external guanidinium ions on fast and slow inactivating currents flowing through sodium channels of the frog myelinated nerve fibre (Benoit, Corbier & Dubois, 1985) were analysed under voltage-clamp conditions. 2. When external sodium ions were partially replaced by guanidinium ions, the fast inactivating current was preferentially reduced and was absent in a solution containing guanidinium ions as the only external permeant cations. The inactivation time constants of both fast and slow currents were not significantly modified by the replacement of sodium ions by guanidinium ions. 3. Substitution of guanidinium ions for all sodium ions shifted the steady-state inactivation curve of the slow inactivating current towards positive voltages. 4. The voltage dependence of the activation of fast and slow inactivating currents was shifted towards positive voltages by guanidinium ions. Moreover, the activation-voltage curve of the slow inactivating current, which was biphasic under control conditions, was monophasic when guanidinium ions were substituted for all sodium ions. 5. Whereas the slow inactivating current could be carried by guanidinium ions, these cations were not only impermeant through the sodium channels which give rise to the fast inactivating current but also blocked this type of channel with an apparent dissociation constant of 49 mM. 6. It is concluded that guanidinium appears to be an efficient tool for further separating the two types of inactivating current and studying the properties of the slow inactivating current. These results are consistent with the suggestion that there are two types of sodium channels, fast and slow, with guanidinium ions being permeant only through the slow ones." @default.
- W2045484927 created "2016-06-24" @default.
- W2045484927 creator A5044519002 @default.
- W2045484927 creator A5060607593 @default.
- W2045484927 date "1987-10-01" @default.
- W2045484927 modified "2023-09-26" @default.
- W2045484927 title "Interactions of guanidinium ions with sodium channels in frog myelinated nerve fibre." @default.
- W2045484927 cites W1482807527 @default.
- W2045484927 cites W1965878712 @default.
- W2045484927 cites W1977347051 @default.
- W2045484927 cites W1991767266 @default.
- W2045484927 cites W2001661928 @default.
- W2045484927 cites W2031154815 @default.
- W2045484927 cites W2034995538 @default.
- W2045484927 cites W2036435511 @default.
- W2045484927 cites W2064379457 @default.
- W2045484927 cites W2071586554 @default.
- W2045484927 cites W2090137487 @default.
- W2045484927 cites W2115838256 @default.
- W2045484927 cites W2132665582 @default.
- W2045484927 cites W2143239901 @default.
- W2045484927 cites W2177922118 @default.
- W2045484927 cites W2331915413 @default.
- W2045484927 cites W2428134338 @default.
- W2045484927 cites W255759321 @default.
- W2045484927 doi "https://doi.org/10.1113/jphysiol.1987.sp016727" @default.
- W2045484927 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1192203" @default.
- W2045484927 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2451015" @default.
- W2045484927 hasPublicationYear "1987" @default.
- W2045484927 type Work @default.
- W2045484927 sameAs 2045484927 @default.
- W2045484927 citedByCount "8" @default.
- W2045484927 crossrefType "journal-article" @default.
- W2045484927 hasAuthorship W2045484927A5044519002 @default.
- W2045484927 hasAuthorship W2045484927A5060607593 @default.
- W2045484927 hasBestOaLocation W20454849272 @default.
- W2045484927 hasConcept C100837961 @default.
- W2045484927 hasConcept C102931765 @default.
- W2045484927 hasConcept C12554922 @default.
- W2045484927 hasConcept C145148216 @default.
- W2045484927 hasConcept C147789679 @default.
- W2045484927 hasConcept C170493617 @default.
- W2045484927 hasConcept C178790620 @default.
- W2045484927 hasConcept C179104552 @default.
- W2045484927 hasConcept C181911157 @default.
- W2045484927 hasConcept C185592680 @default.
- W2045484927 hasConcept C50254741 @default.
- W2045484927 hasConcept C50952357 @default.
- W2045484927 hasConcept C537181965 @default.
- W2045484927 hasConcept C55493867 @default.
- W2045484927 hasConcept C86803240 @default.
- W2045484927 hasConceptScore W2045484927C100837961 @default.
- W2045484927 hasConceptScore W2045484927C102931765 @default.
- W2045484927 hasConceptScore W2045484927C12554922 @default.
- W2045484927 hasConceptScore W2045484927C145148216 @default.
- W2045484927 hasConceptScore W2045484927C147789679 @default.
- W2045484927 hasConceptScore W2045484927C170493617 @default.
- W2045484927 hasConceptScore W2045484927C178790620 @default.
- W2045484927 hasConceptScore W2045484927C179104552 @default.
- W2045484927 hasConceptScore W2045484927C181911157 @default.
- W2045484927 hasConceptScore W2045484927C185592680 @default.
- W2045484927 hasConceptScore W2045484927C50254741 @default.
- W2045484927 hasConceptScore W2045484927C50952357 @default.
- W2045484927 hasConceptScore W2045484927C537181965 @default.
- W2045484927 hasConceptScore W2045484927C55493867 @default.
- W2045484927 hasConceptScore W2045484927C86803240 @default.
- W2045484927 hasLocation W20454849271 @default.
- W2045484927 hasLocation W20454849272 @default.
- W2045484927 hasLocation W20454849273 @default.
- W2045484927 hasOpenAccess W2045484927 @default.
- W2045484927 hasPrimaryLocation W20454849271 @default.
- W2045484927 hasRelatedWork W1984877619 @default.
- W2045484927 hasRelatedWork W2005108928 @default.
- W2045484927 hasRelatedWork W2045484927 @default.
- W2045484927 hasRelatedWork W2059081000 @default.
- W2045484927 hasRelatedWork W2070676751 @default.
- W2045484927 hasRelatedWork W2075037235 @default.
- W2045484927 hasRelatedWork W2094236263 @default.
- W2045484927 hasRelatedWork W2123369785 @default.
- W2045484927 hasRelatedWork W2496036745 @default.
- W2045484927 hasRelatedWork W992809761 @default.
- W2045484927 isParatext "false" @default.
- W2045484927 isRetracted "false" @default.
- W2045484927 magId "2045484927" @default.
- W2045484927 workType "article" @default.