FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045485197> ?p ?o ?g. }

• W2045485197 endingPage "5238" @default.
• W2045485197 startingPage "5233" @default.
• W2045485197 abstract "The intermediates in the oxidation of deoxyhemoglobin by ferricyanide in 0.1 M KCl, at 20 degrees C and three pH values, were studied by cryogenic techniques. Data analysis was carried out according to a simple four rate constant model, ignoring the functional heterogeneity of the subunits, to simulate the time courses of the oxidation reaction, as studied by the stopped-flow technique [Antonini et al., (1965) Biochemistry 4, 345], which show anticooperativity at neutral pH and cooperativity at alkaline pH. Data analysis according to a 12 rate constant model indicated that the rate of oxidation of the beta subunit in the first oxidation reaction was 4 times faster than the rate of oxidation of the alpha subunit at pH 6.2 and 12 times faster at pH 8.5. The reactions involving the alpha subunit were noncooperative except for the last oxidation step at acid and neutral pH, but were cooperative at alkaline pH. The reactions involving the beta subunit were partly noncooperative and partly anticooperative. These complex mechanistic patterns suggest that a simple two-state model requiring the concerted transition of the tertiary structures of the subunits from the T to the R conformation is not adequate to interpret the oxidation reaction and that tertiary structures contribute, positively and negatively, to cooperativity. A structural hypothesis is suggested to explain the difference in the reactivities of the alpha and beta subunits." @default.
• W2045485197 created "2016-06-24" @default.
• W2045485197 creator A5017220612 @default.
• W2045485197 creator A5017998815 @default.
• W2045485197 creator A5043042908 @default.
• W2045485197 creator A5063026944 @default.
• W2045485197 creator A5070881589 @default.
• W2045485197 creator A5073462840 @default.
• W2045485197 date "1993-05-18" @default.
• W2045485197 modified "2023-09-25" @default.
• W2045485197 title "Mechanism of the oxidation reaction of deoxyhemoglobin as studied by isolation of the intermediates suggests tertiary structure dependent cooperativity" @default.
• W2045485197 cites W1497890785 @default.
• W2045485197 cites W1499121860 @default.
• W2045485197 cites W1539518274 @default.
• W2045485197 cites W1556329174 @default.
• W2045485197 cites W1592390035 @default.
• W2045485197 cites W1607028817 @default.
• W2045485197 cites W1620890459 @default.
• W2045485197 cites W1966103618 @default.
• W2045485197 cites W1967104325 @default.
• W2045485197 cites W1991875726 @default.
• W2045485197 cites W1998137737 @default.
• W2045485197 cites W2001638370 @default.
• W2045485197 cites W2004004084 @default.
• W2045485197 cites W2019642924 @default.
• W2045485197 cites W2026911129 @default.
• W2045485197 cites W2038179420 @default.
• W2045485197 cites W2052039588 @default.
• W2045485197 cites W2087601502 @default.
• W2045485197 cites W2093490732 @default.
• W2045485197 cites W4230158786 @default.
• W2045485197 cites W62069120 @default.
• W2045485197 cites W971477019 @default.
• W2045485197 doi "https://doi.org/10.1021/bi00070a035" @default.
• W2045485197 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8494900" @default.
• W2045485197 hasPublicationYear "1993" @default.
• W2045485197 type Work @default.
• W2045485197 sameAs 2045485197 @default.
• W2045485197 citedByCount "13" @default.
• W2045485197 countsByYear W20454851972012 @default.
• W2045485197 countsByYear W20454851972013 @default.
• W2045485197 countsByYear W20454851972022 @default.
• W2045485197 crossrefType "journal-article" @default.
• W2045485197 hasAuthorship W2045485197A5017220612 @default.
• W2045485197 hasAuthorship W2045485197A5017998815 @default.
• W2045485197 hasAuthorship W2045485197A5043042908 @default.
• W2045485197 hasAuthorship W2045485197A5063026944 @default.
• W2045485197 hasAuthorship W2045485197A5070881589 @default.
• W2045485197 hasAuthorship W2045485197A5073462840 @default.
• W2045485197 hasConcept C104292427 @default.
• W2045485197 hasConcept C104317684 @default.
• W2045485197 hasConcept C121332964 @default.
• W2045485197 hasConcept C148898269 @default.
• W2045485197 hasConcept C161790260 @default.
• W2045485197 hasConcept C166014724 @default.
• W2045485197 hasConcept C175113610 @default.
• W2045485197 hasConcept C178790620 @default.
• W2045485197 hasConcept C179104552 @default.
• W2045485197 hasConcept C185592680 @default.
• W2045485197 hasConcept C199360897 @default.
• W2045485197 hasConcept C2776174256 @default.
• W2045485197 hasConcept C2777411777 @default.
• W2045485197 hasConcept C41008148 @default.
• W2045485197 hasConcept C55493867 @default.
• W2045485197 hasConcept C55904794 @default.
• W2045485197 hasConcept C62520636 @default.
• W2045485197 hasConcept C65024703 @default.
• W2045485197 hasConcept C71240020 @default.
• W2045485197 hasConcept C93391505 @default.
• W2045485197 hasConceptScore W2045485197C104292427 @default.
• W2045485197 hasConceptScore W2045485197C104317684 @default.
• W2045485197 hasConceptScore W2045485197C121332964 @default.
• W2045485197 hasConceptScore W2045485197C148898269 @default.
• W2045485197 hasConceptScore W2045485197C161790260 @default.
• W2045485197 hasConceptScore W2045485197C166014724 @default.
• W2045485197 hasConceptScore W2045485197C175113610 @default.
• W2045485197 hasConceptScore W2045485197C178790620 @default.
• W2045485197 hasConceptScore W2045485197C179104552 @default.
• W2045485197 hasConceptScore W2045485197C185592680 @default.
• W2045485197 hasConceptScore W2045485197C199360897 @default.
• W2045485197 hasConceptScore W2045485197C2776174256 @default.
• W2045485197 hasConceptScore W2045485197C2777411777 @default.
• W2045485197 hasConceptScore W2045485197C41008148 @default.
• W2045485197 hasConceptScore W2045485197C55493867 @default.
• W2045485197 hasConceptScore W2045485197C55904794 @default.
• W2045485197 hasConceptScore W2045485197C62520636 @default.
• W2045485197 hasConceptScore W2045485197C65024703 @default.
• W2045485197 hasConceptScore W2045485197C71240020 @default.
• W2045485197 hasConceptScore W2045485197C93391505 @default.
• W2045485197 hasIssue "19" @default.
• W2045485197 hasLocation W20454851971 @default.
• W2045485197 hasLocation W20454851972 @default.
• W2045485197 hasOpenAccess W2045485197 @default.
• W2045485197 hasPrimaryLocation W20454851971 @default.
• W2045485197 hasRelatedWork W182153807 @default.
• W2045485197 hasRelatedWork W1964687069 @default.
• W2045485197 hasRelatedWork W1988093823 @default.
• W2045485197 hasRelatedWork W1989280951 @default.

• next