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• W2045485299 abstract "Ca2+ release from intracellular stores and/or transmembrane influx can increase the cytosolic free Ca2+ concentration ([Ca2+]i). Such changes in [Ca2+]i might transduce signals regulating transcription, motility, secretion, and so on. Surfactant secretagogues such as ATP and ionomycin stimulate the release and transmembrane influx of Ca2+, both of which increase [Ca2+]i. The addition of surfactant protein A (SP-A) or depleting cellular Ca2+ inhibited both surfactant secretion and Ca2+ transients. Current results suggest that Ca2+ signalling stimulates surfactant secretion by type II pneumocytes, but not via increased [Ca2+]i. Treatment of cells with a Ca2+ chelator, bis-(o-aminophenoxy)ethane-N,N,N′,N′-tetra-acetic acid acetoxymethyl ester (BAPTA-AM), stimulated secretion but decreased [Ca2+]i. Adding SP-A or depleting Ca2+ inhibited BAPTA-AM-induced secretion. When studied directly, Ca2+ in the endoplasmic reticulum store ([Ca2+]l) decreased in response to BAPTA, ionomycin and thapsigargin, and increased in response to SP-A. Phorbol ester (PMA) induced surfactant secretion without altering [Ca2+]i or [Ca2+]l and was unaffected by Ca2+ depletion. The addition of PMA to Ca2+-releasing secretagogues increased secretion, but combining two Ca2+-releasing secretagogues did not. These results suggest that (1) Ca2+ signalling of type II cell surfactant secretion reflects changes in [Ca2+]l, not [Ca2+]i, (2) PMA elicits secretion differently from Ca2+-releasing secretagogues, and (3) SP-A inhibits secretion by enhancing Ca2+ sequestration within endoplasmic reticulum stores. Whether other cell types signal via changes in [Ca2+]l is unknown." @default.
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• W2045485299 date "1999-11-08" @default.
• W2045485299 modified "2023-09-23" @default.
• W2045485299 title "Cellular activation by Ca2+ release from stores in the endoplasmic reticulum but not by increased free Ca2+ in the cytosol" @default.
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• W2045485299 doi "https://doi.org/10.1042/bj3440039" @default.
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