Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045486983> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2045486983 endingPage "765" @default.
- W2045486983 startingPage "765" @default.
- W2045486983 abstract "To determine whether an impaired tubular transport mechanism for urate could differentiate the pathogenesis of gouty hyperuricemia and if serum urate influences the renal handling of uric acid, we conducted metabolic studies in 56 patients with primary gout. Tubular reabsorption of urate was normal. Tubular secretory rate was 29.3 ± 8.7 percent of filtered urate as compared to 42.4 ± 4.3 percent in 10 normal subjects for a similar urate filtered load (P < 0.01). Among 30 patients examined in the basal state and at pharmacologically reduced serum urate levels, 24 showed a diminished and 6 normal tubular urate secretion in both states of uricemia. According to the probenecid test, 45 patients evidenced a diminished uricosuric response and 11 normal urate excretion rates. This classification was similar to that obtained by the 24-h urinary urate excretion and was identical to that established by means of [2-14C]uric acid in 8 selected patients. We conclude that an impaired tubular secretion of urate may differentiate gouty underexcretors from uric acid overproducers. Increased serum urate is not the cause but a consequence of the impaired tubular urate secretory mechanism in gout." @default.
- W2045486983 created "2016-06-24" @default.
- W2045486983 creator A5012304432 @default.
- W2045486983 creator A5015446153 @default.
- W2045486983 creator A5028141587 @default.
- W2045486983 creator A5036419325 @default.
- W2045486983 creator A5071151101 @default.
- W2045486983 date "1985-07-01" @default.
- W2045486983 modified "2023-09-25" @default.
- W2045486983 title "DIMINISHED TUBULAR SECRETION OF URATE IN GOUT NOT DEPENDENT ON SERUM URATE LEVELS: 128" @default.
- W2045486983 doi "https://doi.org/10.1203/00006450-198507000-00148" @default.
- W2045486983 hasPublicationYear "1985" @default.
- W2045486983 type Work @default.
- W2045486983 sameAs 2045486983 @default.
- W2045486983 citedByCount "0" @default.
- W2045486983 crossrefType "journal-article" @default.
- W2045486983 hasAuthorship W2045486983A5012304432 @default.
- W2045486983 hasAuthorship W2045486983A5015446153 @default.
- W2045486983 hasAuthorship W2045486983A5028141587 @default.
- W2045486983 hasAuthorship W2045486983A5036419325 @default.
- W2045486983 hasAuthorship W2045486983A5071151101 @default.
- W2045486983 hasBestOaLocation W20454869831 @default.
- W2045486983 hasConcept C10146269 @default.
- W2045486983 hasConcept C126322002 @default.
- W2045486983 hasConcept C134018914 @default.
- W2045486983 hasConcept C185592680 @default.
- W2045486983 hasConcept C2776769776 @default.
- W2045486983 hasConcept C2777601384 @default.
- W2045486983 hasConcept C2778024521 @default.
- W2045486983 hasConcept C2778076174 @default.
- W2045486983 hasConcept C2779721657 @default.
- W2045486983 hasConcept C2779881121 @default.
- W2045486983 hasConcept C2780091579 @default.
- W2045486983 hasConcept C2780402116 @default.
- W2045486983 hasConcept C2780942790 @default.
- W2045486983 hasConcept C49039625 @default.
- W2045486983 hasConcept C555293320 @default.
- W2045486983 hasConcept C56906281 @default.
- W2045486983 hasConcept C71924100 @default.
- W2045486983 hasConceptScore W2045486983C10146269 @default.
- W2045486983 hasConceptScore W2045486983C126322002 @default.
- W2045486983 hasConceptScore W2045486983C134018914 @default.
- W2045486983 hasConceptScore W2045486983C185592680 @default.
- W2045486983 hasConceptScore W2045486983C2776769776 @default.
- W2045486983 hasConceptScore W2045486983C2777601384 @default.
- W2045486983 hasConceptScore W2045486983C2778024521 @default.
- W2045486983 hasConceptScore W2045486983C2778076174 @default.
- W2045486983 hasConceptScore W2045486983C2779721657 @default.
- W2045486983 hasConceptScore W2045486983C2779881121 @default.
- W2045486983 hasConceptScore W2045486983C2780091579 @default.
- W2045486983 hasConceptScore W2045486983C2780402116 @default.
- W2045486983 hasConceptScore W2045486983C2780942790 @default.
- W2045486983 hasConceptScore W2045486983C49039625 @default.
- W2045486983 hasConceptScore W2045486983C555293320 @default.
- W2045486983 hasConceptScore W2045486983C56906281 @default.
- W2045486983 hasConceptScore W2045486983C71924100 @default.
- W2045486983 hasIssue "7" @default.
- W2045486983 hasLocation W20454869831 @default.
- W2045486983 hasOpenAccess W2045486983 @default.
- W2045486983 hasPrimaryLocation W20454869831 @default.
- W2045486983 hasRelatedWork W1707626557 @default.
- W2045486983 hasRelatedWork W1965635144 @default.
- W2045486983 hasRelatedWork W1973166439 @default.
- W2045486983 hasRelatedWork W1996847548 @default.
- W2045486983 hasRelatedWork W1997591606 @default.
- W2045486983 hasRelatedWork W2045486983 @default.
- W2045486983 hasRelatedWork W2052873939 @default.
- W2045486983 hasRelatedWork W2056297858 @default.
- W2045486983 hasRelatedWork W2149786401 @default.
- W2045486983 hasRelatedWork W2419314162 @default.
- W2045486983 hasVolume "19" @default.
- W2045486983 isParatext "false" @default.
- W2045486983 isRetracted "false" @default.
- W2045486983 magId "2045486983" @default.
- W2045486983 workType "article" @default.