FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045488908> ?p ?o ?g. }

• W2045488908 endingPage "1237" @default.
• W2045488908 startingPage "1227" @default.
• W2045488908 abstract "Nonsteroidal anti-inflammatory drugs (NSAIDs), both nonselective and cyclooxygenase-2–specific inhibitors, are commonly used medications for the relief of acute and chronic pain associated with a wide range of medical conditions. Because of the extensive use of these agents, adverse events that occur infrequently may still affect the overall risk/benefit ratio of this class of medications. Serious adverse cardiovascular (CV) events have been reported with NSAID use, but unfortunately, definitive evidence regarding the precise CV risk associated with these drugs, as a class and individually, is lacking. Therefore, it is an issue of public health importance that physicians be guided by careful assessment of the existing evidence to make reasonable choices in prescribing these medications. The investigators review the key clinical trials, meta-analyses of clinical trials, and epidemiologic studies on the subject of the CV safety of NSAIDs and identify key variables that define the CV risk of the NSAIDs. In conclusion, it is important that cardiologists, who are not among those physicians frequently prescribing NSAIDs, have a particular responsibility to have up-to-date, thoughtfully synthesized information about the CV risks of these drugs, especially when administered to patients receiving low-dose aspirin for cardioprotection. Nonsteroidal anti-inflammatory drugs (NSAIDs), both nonselective and cyclooxygenase-2–specific inhibitors, are commonly used medications for the relief of acute and chronic pain associated with a wide range of medical conditions. Because of the extensive use of these agents, adverse events that occur infrequently may still affect the overall risk/benefit ratio of this class of medications. Serious adverse cardiovascular (CV) events have been reported with NSAID use, but unfortunately, definitive evidence regarding the precise CV risk associated with these drugs, as a class and individually, is lacking. Therefore, it is an issue of public health importance that physicians be guided by careful assessment of the existing evidence to make reasonable choices in prescribing these medications. The investigators review the key clinical trials, meta-analyses of clinical trials, and epidemiologic studies on the subject of the CV safety of NSAIDs and identify key variables that define the CV risk of the NSAIDs. In conclusion, it is important that cardiologists, who are not among those physicians frequently prescribing NSAIDs, have a particular responsibility to have up-to-date, thoughtfully synthesized information about the CV risks of these drugs, especially when administered to patients receiving low-dose aspirin for cardioprotection. Reducing Cardiovascular Risks of Nonsteroidal Anti-Inflammatory Drugs by Using Topical FormulationsAmerican Journal of CardiologyVol. 104Issue 9PreviewFarkouh and Greenberg1 presented a timely and valuable review of the cardiovascular risk profiles of nonsteroidal anti-inflammatory drugs (NSAIDs). This review is of clinical importance because of the widespread availability and monitored and unmonitored use of NSAIDs, coupled with their potential to affect multiple organs, including the cardiovascular system. However, a discussion of topical NSAIDs is absent from this review. International guidelines recommend considering topical NSAIDs as a first-line therapy for osteoarthritis of the knees2 and hands. Full-Text PDF" @default.
• W2045488908 created "2016-06-24" @default.
• W2045488908 creator A5043621364 @default.
• W2045488908 creator A5057092613 @default.
• W2045488908 date "2009-05-01" @default.
• W2045488908 modified "2023-10-03" @default.
• W2045488908 title "An Evidence-Based Review of the Cardiovascular Risks of Nonsteroidal Anti-Inflammatory Drugs" @default.
• W2045488908 cites W1974171016 @default.
• W2045488908 cites W1975563305 @default.
• W2045488908 cites W1983393465 @default.
• W2045488908 cites W1997232787 @default.
• W2045488908 cites W2011327495 @default.
• W2045488908 cites W2011941025 @default.
• W2045488908 cites W2012920835 @default.
• W2045488908 cites W2014184499 @default.
• W2045488908 cites W2024233889 @default.
• W2045488908 cites W2037099926 @default.
• W2045488908 cites W2038932922 @default.
• W2045488908 cites W2049978602 @default.
• W2045488908 cites W2051826678 @default.
• W2045488908 cites W2051874551 @default.
• W2045488908 cites W2052530234 @default.
• W2045488908 cites W2057685090 @default.
• W2045488908 cites W2065034296 @default.
• W2045488908 cites W2067621583 @default.
• W2045488908 cites W2095750608 @default.
• W2045488908 cites W2100631748 @default.
• W2045488908 cites W2106346422 @default.
• W2045488908 cites W2115903771 @default.
• W2045488908 cites W2117784691 @default.
• W2045488908 cites W2130517249 @default.
• W2045488908 cites W2133278537 @default.
• W2045488908 cites W2134234269 @default.
• W2045488908 cites W2134634779 @default.
• W2045488908 cites W2134913491 @default.
• W2045488908 cites W2135393211 @default.
• W2045488908 cites W2136486607 @default.
• W2045488908 cites W2139776244 @default.
• W2045488908 cites W2145816148 @default.
• W2045488908 cites W2145839235 @default.
• W2045488908 cites W2158131645 @default.
• W2045488908 cites W2158968701 @default.
• W2045488908 cites W2163756514 @default.
• W2045488908 cites W2167792025 @default.
• W2045488908 cites W2330496155 @default.
• W2045488908 cites W4239471829 @default.
• W2045488908 cites W4249588068 @default.
• W2045488908 cites W4255226843 @default.
• W2045488908 doi "https://doi.org/10.1016/j.amjcard.2009.01.014" @default.
• W2045488908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19406264" @default.
• W2045488908 hasPublicationYear "2009" @default.
• W2045488908 type Work @default.
• W2045488908 sameAs 2045488908 @default.
• W2045488908 citedByCount "122" @default.
• W2045488908 countsByYear W20454889082012 @default.
• W2045488908 countsByYear W20454889082013 @default.
• W2045488908 countsByYear W20454889082014 @default.
• W2045488908 countsByYear W20454889082015 @default.
• W2045488908 countsByYear W20454889082016 @default.
• W2045488908 countsByYear W20454889082017 @default.
• W2045488908 countsByYear W20454889082018 @default.
• W2045488908 countsByYear W20454889082019 @default.
• W2045488908 countsByYear W20454889082020 @default.
• W2045488908 countsByYear W20454889082021 @default.
• W2045488908 countsByYear W20454889082022 @default.
• W2045488908 countsByYear W20454889082023 @default.
• W2045488908 crossrefType "journal-article" @default.
• W2045488908 hasAuthorship W2045488908A5043621364 @default.
• W2045488908 hasAuthorship W2045488908A5057092613 @default.
• W2045488908 hasConcept C126322002 @default.
• W2045488908 hasConcept C177713679 @default.
• W2045488908 hasConcept C197934379 @default.
• W2045488908 hasConcept C2777628954 @default.
• W2045488908 hasConcept C2778176773 @default.
• W2045488908 hasConcept C2778484676 @default.
• W2045488908 hasConcept C2780035454 @default.
• W2045488908 hasConcept C535046627 @default.
• W2045488908 hasConcept C71924100 @default.
• W2045488908 hasConcept C98274493 @default.
• W2045488908 hasConceptScore W2045488908C126322002 @default.
• W2045488908 hasConceptScore W2045488908C177713679 @default.
• W2045488908 hasConceptScore W2045488908C197934379 @default.
• W2045488908 hasConceptScore W2045488908C2777628954 @default.
• W2045488908 hasConceptScore W2045488908C2778176773 @default.
• W2045488908 hasConceptScore W2045488908C2778484676 @default.
• W2045488908 hasConceptScore W2045488908C2780035454 @default.
• W2045488908 hasConceptScore W2045488908C535046627 @default.
• W2045488908 hasConceptScore W2045488908C71924100 @default.
• W2045488908 hasConceptScore W2045488908C98274493 @default.
• W2045488908 hasIssue "9" @default.
• W2045488908 hasLocation W20454889081 @default.
• W2045488908 hasLocation W20454889082 @default.
• W2045488908 hasOpenAccess W2045488908 @default.
• W2045488908 hasPrimaryLocation W20454889081 @default.
• W2045488908 hasRelatedWork W125288044 @default.
• W2045488908 hasRelatedWork W1995165714 @default.
• W2045488908 hasRelatedWork W2003867452 @default.
• W2045488908 hasRelatedWork W2013786158 @default.

• next