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• W2045489240 abstract "1,3-Disubstituted-5-aminopyrazoles were prepared based on a lead compound found through high-throughput screening of our corporate compound library in an assay measuring affinity for the human neuropeptide Y5 receptor. The target compounds were prepared by cyclization of alpha-cyanoketones with appropriate hydrazines, followed by reduction and coupling to various sulfonamido-carboxylic acids. Several of these arylpyrazoles (e.g., 19 and 45) displayed high affinity for the human NPY Y5 receptor (<20nM IC(50)s)." @default.
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• W2045489240 date "2001-09-01" @default.
• W2045489240 modified "2023-09-23" @default.
• W2045489240 title "Aminopyrazoles with high affinity for the human neuropeptide Y5 receptor" @default.
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• W2045489240 doi "https://doi.org/10.1016/s0960-894x(01)00448-6" @default.
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