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- W2045489285 endingPage "471" @default.
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- W2045489285 abstract "Base sequence information can be stored in the local structure of right-handed double-helical DNA (B-DNA). The question arises as to whether a set of rules for the three-dimensional readout of the B-DNA helix can be developed. This would allow the design of synthetic molecules that bind DNA of any specific sequence and site size. There are four stages of development for each new synthetic sequence-specific DNA-binding molecule: design, synthesis, testing for sequence specificity, and reevaluation of the design. This approach has produced bis(distamycin)fumaramide, a synthetic, crescent-shaped oligopeptide that binds nine contiguous adenine-thymine base pairs in the minor groove of double-helical DNA." @default.
- W2045489285 created "2016-06-24" @default.
- W2045489285 creator A5076578241 @default.
- W2045489285 date "1986-04-25" @default.
- W2045489285 modified "2023-10-16" @default.
- W2045489285 title "Design of Sequence-Specific DNA-Binding Molecules" @default.
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- W2045489285 doi "https://doi.org/10.1126/science.2421408" @default.
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