FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045490695> ?p ?o ?g. }

• W2045490695 endingPage "e6266" @default.
• W2045490695 startingPage "e6266" @default.
• W2045490695 abstract "Sequence similarity to characterized proteins provides testable functional hypotheses for less than 50% of the proteins identified by genome sequencing projects. With structural genomics it is believed that structural similarities may give functional hypotheses for many of the remaining proteins.We provide a systematic analysis of the structure-function relationship in proteins using the novel concept of local descriptors of protein structure. A local descriptor is a small substructure of a protein which includes both short- and long-range interactions. We employ a library of commonly reoccurring local descriptors general enough to assemble most existing protein structures. We then model the relationship between these local shapes and Gene Ontology using rule-based learning. Our IF-THEN rule model offers legible, high resolution descriptions that combine local substructures and is able to discriminate functions even for functionally versatile folds such as the frequently occurring TIM barrel and Rossmann fold. By evaluating the predictive performance of the model, we provide a comprehensive quantification of the structure-function relationship based only on local structure similarity. Our findings are, among others, that conserved structure is a stronger prerequisite for enzymatic activity than for binding specificity, and that structure-based predictions complement sequence-based predictions. The model is capable of generating correct hypotheses, as confirmed by a literature study, even when no significant sequence similarity to characterized proteins exists.Our approach offers a new and complete description and quantification of the structure-function relationship in proteins. By demonstrating how our predictions offer higher sensitivity than using global structure, and complement the use of sequence, we show that the presented ideas could advance the development of meta-servers in function prediction." @default.
• W2045490695 created "2016-06-24" @default.
• W2045490695 creator A5022568938 @default.
• W2045490695 creator A5046112262 @default.
• W2045490695 creator A5050406527 @default.
• W2045490695 creator A5069533024 @default.
• W2045490695 creator A5074974770 @default.
• W2045490695 creator A5084054353 @default.
• W2045490695 date "2009-07-15" @default.
• W2045490695 modified "2023-10-17" @default.
• W2045490695 title "A Comprehensive Analysis of the Structure-Function Relationship in Proteins Based on Local Structure Similarity" @default.
• W2045490695 cites W1530397352 @default.
• W2045490695 cites W1557923305 @default.
• W2045490695 cites W1970697508 @default.
• W2045490695 cites W1970829756 @default.
• W2045490695 cites W1993731989 @default.
• W2045490695 cites W2021639324 @default.
• W2045490695 cites W2039573534 @default.
• W2045490695 cites W2045119694 @default.
• W2045490695 cites W2046002103 @default.
• W2045490695 cites W2048947602 @default.
• W2045490695 cites W2051895548 @default.
• W2045490695 cites W2055779068 @default.
• W2045490695 cites W2073745520 @default.
• W2045490695 cites W2083339788 @default.
• W2045490695 cites W2083654996 @default.
• W2045490695 cites W2100494857 @default.
• W2045490695 cites W2101595316 @default.
• W2045490695 cites W2101842792 @default.
• W2045490695 cites W2102612168 @default.
• W2045490695 cites W2103017472 @default.
• W2045490695 cites W2108067237 @default.
• W2045490695 cites W2110065044 @default.
• W2045490695 cites W2116435022 @default.
• W2045490695 cites W2116751407 @default.
• W2045490695 cites W2121265934 @default.
• W2045490695 cites W2128936012 @default.
• W2045490695 cites W2130479394 @default.
• W2045490695 cites W2132094529 @default.
• W2045490695 cites W2132166479 @default.
• W2045490695 cites W2132844390 @default.
• W2045490695 cites W2134788911 @default.
• W2045490695 cites W2143011057 @default.
• W2045490695 cites W2145358391 @default.
• W2045490695 cites W2147853461 @default.
• W2045490695 cites W2157825442 @default.
• W2045490695 cites W2158369502 @default.
• W2045490695 cites W2158714788 @default.
• W2045490695 cites W2159400443 @default.
• W2045490695 cites W2170471837 @default.
• W2045490695 cites W2171172158 @default.
• W2045490695 cites W2171602500 @default.
• W2045490695 doi "https://doi.org/10.1371/journal.pone.0006266" @default.
• W2045490695 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2705683" @default.
• W2045490695 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19603073" @default.
• W2045490695 hasPublicationYear "2009" @default.
• W2045490695 type Work @default.
• W2045490695 sameAs 2045490695 @default.
• W2045490695 citedByCount "35" @default.
• W2045490695 countsByYear W20454906952012 @default.
• W2045490695 countsByYear W20454906952014 @default.
• W2045490695 countsByYear W20454906952015 @default.
• W2045490695 countsByYear W20454906952016 @default.
• W2045490695 countsByYear W20454906952018 @default.
• W2045490695 countsByYear W20454906952019 @default.
• W2045490695 countsByYear W20454906952020 @default.
• W2045490695 countsByYear W20454906952021 @default.
• W2045490695 countsByYear W20454906952022 @default.
• W2045490695 countsByYear W20454906952023 @default.
• W2045490695 crossrefType "journal-article" @default.
• W2045490695 hasAuthorship W2045490695A5022568938 @default.
• W2045490695 hasAuthorship W2045490695A5046112262 @default.
• W2045490695 hasAuthorship W2045490695A5050406527 @default.
• W2045490695 hasAuthorship W2045490695A5069533024 @default.
• W2045490695 hasAuthorship W2045490695A5074974770 @default.
• W2045490695 hasAuthorship W2045490695A5084054353 @default.
• W2045490695 hasBestOaLocation W20454906951 @default.
• W2045490695 hasConcept C103278499 @default.
• W2045490695 hasConcept C104317684 @default.
• W2045490695 hasConcept C112313634 @default.
• W2045490695 hasConcept C115961682 @default.
• W2045490695 hasConcept C127716648 @default.
• W2045490695 hasConcept C136475424 @default.
• W2045490695 hasConcept C139489369 @default.
• W2045490695 hasConcept C14036430 @default.
• W2045490695 hasConcept C154945302 @default.
• W2045490695 hasConcept C167625842 @default.
• W2045490695 hasConcept C18051474 @default.
• W2045490695 hasConcept C188082640 @default.
• W2045490695 hasConcept C192772702 @default.
• W2045490695 hasConcept C207060522 @default.
• W2045490695 hasConcept C2778112365 @default.
• W2045490695 hasConcept C2986374874 @default.
• W2045490695 hasConcept C41008148 @default.
• W2045490695 hasConcept C41584329 @default.
• W2045490695 hasConcept C45475804 @default.
• W2045490695 hasConcept C45484198 @default.
• W2045490695 hasConcept C4668613 @default.

• next