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- W2045490933 abstract "<h3>Background</h3> The study aimed to evaluate the use of positron emission tomography/computed tomography (PET/CT) with <sup>68</sup>Ga-PRGD2 as the tracer for imaging of synovial angiogenesis in patients with rheumatoid arthritis (RA). <h3>Methods</h3> Twenty untreated active patients with RA underwent <sup>68</sup>Ga-PRGD2 PET/CT and <sup>18</sup>F-FDG PET/CT before treatment; two patients with osteoarthritis served as controls. Among the 20 patients with RA, 12 repeated the evaluations after 3-month treatment. The image findings were correlated with core variables of disease activity, including the clinical disease activity index (cDAI). <h3>Results</h3> Our findings demonstrated that <sup>68</sup>Ga-PRGD2 specifically accumulated in the synovia with active inflammation rich in neovasculature with high-level α<sub>v</sub>β<sub>3</sub>-integrin expression, but not in the <sup>18</sup>F-FDG-avid inflammatory lymph nodes. In patients with intense <sup>18</sup>F-FDG uptake in muscles caused by arthritic pain, we observed that <sup>68</sup>Ga-PRGD2 PET/CT was better able to evaluate disease severity than <sup>18</sup>F-FDG PET/CT. Both <sup>68</sup>Ga-PRGD2 accumulation and <sup>18</sup>F-FDG uptake changed in response to therapeutic intervention, whereas the changes of <sup>68</sup>Ga-PRGD2, not <sup>18</sup>F-FDG, significantly correlated with clinical measures of changes in the form of cDAI. <h3>Conclusions</h3> This is the first integrin imaging study conducted in patients with RA that preliminarily indicates the effectiveness of the novel method for evaluating synovial angiogenesis. <h3>Clinical trial registration</h3> This study has been registered online at NIH ClinicalTrial.gov (NCT01940926)." @default.
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- W2045490933 date "1938-02-19" @default.
- W2045490933 modified "2023-10-16" @default.
- W2045490933 title "Expulsion of Placenta Praevia in Advance of Foetus" @default.
- W2045490933 doi "https://doi.org/10.1136/bmj.1.4024.420" @default.
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