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• W2045491035 abstract "Hyperpolarized (HP) 129Xe yields high signal intensities in nuclear magnetic resonance (NMR) and, through its large chemical shift range of ∼300 ppm, provides detailed information about the local chemical environment. To exploit these properties in aqueous solutions and living tissues requires the development of methods for efficiently dissolving HP 129Xe over an extended time period. To this end, we have used commercially available gas exchange modules to continuously infuse concentrated HP 129Xe into flowing liquids, including rat whole blood, for periods as long as one hour and have demonstrated the feasibility of dissolved-phase MR imaging with submillimeter resolution within minutes. These modules, which exchange gases using hydrophobic microporous polymer membranes, are compatible with a variety of liquids and are suitable for infusing HP 129Xe into the bloodstream in vivo. Additionally, we have developed a detailed mathematical model of the infused HP 129Xe signal dynamics that should be useful in designing improved infusion systems that yield even higher dissolved HP 129Xe signal intensities." @default.
• W2045491035 created "2016-06-24" @default.
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• W2045491035 date "2009-08-24" @default.
• W2045491035 modified "2023-09-25" @default.
• W2045491035 title "Continuously Infusing Hyperpolarized ¹²⁹Xe into Flowing Aqueous Solutions Using Hydrophobic Gas Exchange Membranes" @default.
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• W2045491035 doi "https://doi.org/10.1021/jp9049582" @default.
• W2045491035 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2747043" @default.
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