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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045492000> ?p ?o ?g. }

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• W2045492000 abstract "Extracellular free radicals were detected in rat striatal perfusate samples by intracerebral microdialysis coupled to the spin trapping technique. Five Sprague-Dawley rats were subjected to 30 min of global ischemia followed by reperfusion; throughout the experimental period the intrastriatal dialysing probe was perfused with Ringer's solution containing the spin trap agent pyridyl-N-oxide-t-butylnitrone (100 mM) together with the iron chelating agent diethylentriaminepentacetic acid (100 microM). A radical adduct occurred during ischemia and early reperfusion, but not in basal conditions; the spin adduct was characterized as a carbon centered radical, consistent with the presence of an oxidative attack on membrane lipids. The direct evidence of the formation of free radicals supports the hypothesis that free radicals play a role in the pathogenesis of the histological damage during brain ischemia." @default.
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• W2045492000 date "1992-04-01" @default.
• W2045492000 modified "2023-10-14" @default.
• W2045492000 title "Detection of free radicals during brain ischemia and reperfusion by spin trapping and microdialysis" @default.
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• W2045492000 doi "https://doi.org/10.1016/0304-3940(92)90933-x" @default.
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