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- W2045492315 abstract "A spin-off of malaria-vaccine research has been the development of immunological tests that allow the detection of malaria antigens in the peripheral blood, which could limit the prophylactic use of drugs. Two commercially available tests reveal the Histidine-rich protein 2 (HRP-2) of Plasmodium falciparum (ParaSight-F, Becton-Dickinson and ICT Malaria P.f. test, ICT Diagnostics). The third test detects the lactate dehydrogenase (LDH) enzyme of Plasmodium parasites (OptiMal, Flow Inc.), and allows differentiation between P. falciparum and P. vivax infections. The sensitivity and specificity of the two tests that detect HRP-2 have been evaluated by comparing results with those obtained using microscopy and PCR. In comparison with microscopy, the sensitivity varied from 84–94%, and specificity from 81–99.5%. The range of positive- and negative-predicting values was 80–99% and 64–100%, respectively. The investigators conclude that although these tests are regarded as an aid in the diagnosis, they cannot be relied upon to diagnose a serious disease such as malaria, especially because late diagnosis and treatment are associated with fatal infections. (source: www.isis.rivm.nl/inf_bul/bul101). TS" @default.
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- W2045492315 title "Malaria diagnostic for back-packers" @default.
- W2045492315 doi "https://doi.org/10.1016/s1471-4922(01)02070-0" @default.
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