Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045492435> ?p ?o ?g. }
- W2045492435 endingPage "74" @default.
- W2045492435 startingPage "61" @default.
- W2045492435 abstract "Human embryonic stem cells (hESC) differentiate into trophoblast when treated with BMP4. Here we studied the effects of either low (4 % O(2), L) or atmospheric O(2) (20% O(2), A) in the presence and absence of FGF2 on H1 hESC cultured in presence of BMP4. Differentiation progressed from the periphery towards the center of colonies. It occurred most quickly in the absence of FGF2 and under A and was slowest in presence of FGF2 and under L. Chorionic gonadotrophin (CG) production required A while FGF2 suppressed progesterone synthesis under both A and L. FGF2 was then omitted while we examined trophoblast markers SSEA-1 and cytokeratin-7 and -8, whose expression also progressed inwards from the periphery of colonies and occurred more rapidly under A than L. By day 5, most cells outside central islands of Oct4-positive cells were positive for these antigens under both conditions and many also expressed HLA-G, a marker of extra-villous cytotrophoblast. Under A, but not L, CGalpha and CGbeta became prominent in GATA2-positive, peripherally located, multinucleated cells. In conclusion, BMP4 induced conversion of hESC exclusively towards trophoblast; FGF2 slowed differentiation, while O(2) accelerated this process and promoted syncytiotrophoblast formation." @default.
- W2045492435 created "2016-06-24" @default.
- W2045492435 creator A5024354148 @default.
- W2045492435 creator A5024963760 @default.
- W2045492435 creator A5025054004 @default.
- W2045492435 creator A5034637795 @default.
- W2045492435 creator A5042138855 @default.
- W2045492435 creator A5074767643 @default.
- W2045492435 date "2007-10-01" @default.
- W2045492435 modified "2023-10-17" @default.
- W2045492435 title "Effects of FGF2 and oxygen in the BMP4-driven differentiation of trophoblast from human embryonic stem cells" @default.
- W2045492435 cites W1515916789 @default.
- W2045492435 cites W1599568627 @default.
- W2045492435 cites W1608762409 @default.
- W2045492435 cites W171819190 @default.
- W2045492435 cites W1774192863 @default.
- W2045492435 cites W1842943643 @default.
- W2045492435 cites W1971552887 @default.
- W2045492435 cites W1975237339 @default.
- W2045492435 cites W1985703183 @default.
- W2045492435 cites W1987803647 @default.
- W2045492435 cites W1988219173 @default.
- W2045492435 cites W1992949513 @default.
- W2045492435 cites W1994865551 @default.
- W2045492435 cites W2002915057 @default.
- W2045492435 cites W2024351235 @default.
- W2045492435 cites W2024459158 @default.
- W2045492435 cites W2031257597 @default.
- W2045492435 cites W2032665278 @default.
- W2045492435 cites W2034234454 @default.
- W2045492435 cites W2053510054 @default.
- W2045492435 cites W2056089399 @default.
- W2045492435 cites W2061004792 @default.
- W2045492435 cites W2070069826 @default.
- W2045492435 cites W2071700852 @default.
- W2045492435 cites W2072177711 @default.
- W2045492435 cites W2072556950 @default.
- W2045492435 cites W2074137603 @default.
- W2045492435 cites W2075951990 @default.
- W2045492435 cites W2078955788 @default.
- W2045492435 cites W2082292567 @default.
- W2045492435 cites W2085503695 @default.
- W2045492435 cites W2086943348 @default.
- W2045492435 cites W2088088839 @default.
- W2045492435 cites W2089611230 @default.
- W2045492435 cites W2090883212 @default.
- W2045492435 cites W2094309285 @default.
- W2045492435 cites W2102175828 @default.
- W2045492435 cites W2102277066 @default.
- W2045492435 cites W2105767263 @default.
- W2045492435 cites W2106365461 @default.
- W2045492435 cites W2110301828 @default.
- W2045492435 cites W2115095005 @default.
- W2045492435 cites W2131545249 @default.
- W2045492435 cites W2131869707 @default.
- W2045492435 cites W2131965270 @default.
- W2045492435 cites W2133501984 @default.
- W2045492435 cites W2134128560 @default.
- W2045492435 cites W2135578995 @default.
- W2045492435 cites W2142001424 @default.
- W2045492435 cites W2142037464 @default.
- W2045492435 cites W2156797363 @default.
- W2045492435 cites W2167503858 @default.
- W2045492435 cites W2170289251 @default.
- W2045492435 cites W2410060723 @default.
- W2045492435 cites W4234389174 @default.
- W2045492435 doi "https://doi.org/10.1016/j.scr.2007.09.004" @default.
- W2045492435 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2634289" @default.
- W2045492435 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19194525" @default.
- W2045492435 hasPublicationYear "2007" @default.
- W2045492435 type Work @default.
- W2045492435 sameAs 2045492435 @default.
- W2045492435 citedByCount "83" @default.
- W2045492435 countsByYear W20454924352012 @default.
- W2045492435 countsByYear W20454924352013 @default.
- W2045492435 countsByYear W20454924352014 @default.
- W2045492435 countsByYear W20454924352015 @default.
- W2045492435 countsByYear W20454924352016 @default.
- W2045492435 countsByYear W20454924352017 @default.
- W2045492435 countsByYear W20454924352018 @default.
- W2045492435 countsByYear W20454924352019 @default.
- W2045492435 countsByYear W20454924352020 @default.
- W2045492435 countsByYear W20454924352021 @default.
- W2045492435 countsByYear W20454924352022 @default.
- W2045492435 countsByYear W20454924352023 @default.
- W2045492435 crossrefType "journal-article" @default.
- W2045492435 hasAuthorship W2045492435A5024354148 @default.
- W2045492435 hasAuthorship W2045492435A5024963760 @default.
- W2045492435 hasAuthorship W2045492435A5025054004 @default.
- W2045492435 hasAuthorship W2045492435A5034637795 @default.
- W2045492435 hasAuthorship W2045492435A5042138855 @default.
- W2045492435 hasAuthorship W2045492435A5074767643 @default.
- W2045492435 hasBestOaLocation W20454924352 @default.
- W2045492435 hasConcept C104317684 @default.
- W2045492435 hasConcept C126322002 @default.
- W2045492435 hasConcept C134018914 @default.
- W2045492435 hasConcept C136403682 @default.
- W2045492435 hasConcept C145103041 @default.