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• W2045493079 abstract "No AccessJournal of UrologyTissue Engineering/Embryology1 Oct 2004THE PROSTATIC UTRICLE IS NOT A MÜLLERIAN DUCT REMNANT: IMMUNOHISTOCHEMICAL EVIDENCE FOR A DISTINCT UROGENITAL SINUS ORIGIN ELLEN SHAPIRO, HONGYING HUANG, DEBORAH E. McFADDEN, RACHEL J. MASCH, ELIZA NG, HERBERT LEPOR, and XUE-RU WU ELLEN SHAPIROELLEN SHAPIRO More articles by this author , HONGYING HUANGHONGYING HUANG More articles by this author , DEBORAH E. McFADDENDEBORAH E. McFADDEN More articles by this author , RACHEL J. MASCHRACHEL J. MASCH More articles by this author , ELIZA NGELIZA NG More articles by this author , HERBERT LEPORHERBERT LEPOR More articles by this author , and XUE-RU WUXUE-RU WU More articles by this author View All Author Informationhttps://doi.org/10.1097/01.ju.0000140267.46772.7dAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: The embryological origin of the utricle is thought to be a remnant of the fused caudal ends of the müllerian ducts (MDs). Others propose that the urogenital sinus (UGS) contributes either partially or totally to the development of this structure. Using immunohistochemical probes, we provide strong evidence that the utricle is of UGS origin only. Materials and Methods: Human fetal prostates, gestational ages 9 to 24 weeks, were serially cross-sectioned. Representative sections were stained with antibodies to p63 (basal cell marker), vimentin (mesoderm marker), uroplakins (marker for urothelium) Pax-2 (expressed in ductal and mesenchyme of urogenital system including the MDs and wolffian ducts) and Ki67 (proliferation). Apoptosis was detected with the TUNEL assay. Results: By 9 weeks there was weak expression of p63 in the basal layer of the UGS. At 11 weeks there was increased staining of p63 in the UGS and some p63 staining of the fused MDs, which expressed Pax-2 at this time. At 14 to 15 weeks as the MDs were undergoing apoptosis, there was an ingrowth of uroplakin-expressing UGS epithelium into the periurethral stroma, which formed a plate of p63 positive cells just beneath the UGS that was Ki67 positive. The remaining caudal MD epithelium was p63 negative and expressed vimentin and Pax-2. By 17 weeks the plate of p63 positive cells elongated forming the utricle that remained p63 positive but Pax-2 and vimentin negative. Conclusions: We show that the utricle forms as an ingrowth of specialized cells from the dorsal wall of the UGS as the caudal MDs regress. References 1 : Zur Entwicklungsgeschichte und Anatomie des Utriculus prostaticus beim Menschen. Arch Mikrosk Anat1909; 74: 844. Google Scholar 2 : The development of the utricle and of the so-called “middle” or “median” lobe of the human prostate. J Anat1962; 96: 443. Google Scholar 3 : Uber die Entwicklung des Utriculus prostaticus beim Menschen. Z Anat Entwickl Gesch1932; 99: 399. Google Scholar 4 : Morphological and immunohistochemical investigations of the utriculus prostaticus from the fetal period up to adulthood. Prostate1990; 17: 19. Google Scholar 5 : Large scale purification and immunolocalization of bovine uroplakins I, II, and III. Molecular markers of urothelial differentiation. J Biol Chem1990; 265: 19170. Crossref, Medline, Google Scholar 6 : Roles of p63 in differentiation of müllerian duct epithelial cells. 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Google Scholar From the Departments of Urology (ES, HH, HL, X-RW) and Obstetrics and Gynecology (RJM, EN), New York University School of Medicine, New York, New York, and Department of Pathology, Children's and Women's Centre of British Columbia (DEM), Vancouver, British Columbia© 2004 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited bySHAPIRO E, HUANG H, MASCH R, McFADDEN D, WILSON E and WU X (2018) IMMUNOLOCALIZATION OF ESTROGEN RECEPTOR α AND β IN HUMAN FETAL PROSTATEJournal of Urology, VOL. 174, NO. 5, (2051-2053), Online publication date: 1-Nov-2005.SHAPIRO E, HUANG H, MASCH R, McFADDEN D, WU X and OSTRER H (2018) IMMUNOLOCALIZATION OF ANDROGEN RECEPTOR AND ESTROGEN RECEPTORS α AND β IN HUMAN FETAL TESTIS AND EPIDIDYMISJournal of Urology, VOL. 174, NO. 4 Part 2, (1695-1698), Online publication date: 1-Oct-2005. Volume 172Issue 4 Part 2October 2004Page: 1753-1756 Advertisement Copyright & Permissions© 2004 by American Urological Association, Inc.Keywordsembryologymullerian ductsMetricsAuthor Information ELLEN SHAPIRO More articles by this author HONGYING HUANG More articles by this author DEBORAH E. McFADDEN More articles by this author RACHEL J. MASCH More articles by this author ELIZA NG More articles by this author HERBERT LEPOR More articles by this author XUE-RU WU More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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