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- W2045493897 abstract "Whether carbapenem or fluoroquinolone usage is correlated with carbapenem-resistant Enterobacteriaceae (CRE) has not been investigated at the level of an entire US nationwide managed health care system. We analyzed 75 million person-years of surveillance and 1,969,315 cultures from all 266 hospitals in the geographically dispersed US military health system. Incidences of CRE remained under 1 case per 100,000 person-years. Incidences of CRE increased relative to 2005 baseline levels in 3 of 7 subsequent years, then decreased in 2012 (P < 0.05). Incident proportions of carbapenem resistance (CR) differed significantly among years, geographical regions, and bacterial species. Although use and resistance strongly correlated (R > 0.80) for several “drug-bug” combinations, none were significant at the national or facility level. One exception was that inpatient consumption of fluoroquinolones was significantly correlated (P = 0.0007) with CR in Escherichia coli when data from the major referral centers of the Southern and Northern regions were combined." @default.
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- W2045493897 date "2015-02-01" @default.
- W2045493897 modified "2023-09-27" @default.
- W2045493897 title "Carbapenem-resistant Enterobacteriaceae and the correlation between carbapenem and fluoroquinolone usage and resistance in the US military health system" @default.
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- W2045493897 doi "https://doi.org/10.1016/j.diagmicrobio.2014.09.017" @default.
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